methyl N2,N6-bis(3,4,5-tris(benzyloxy)benzoyl)-L-lysinate | 1446912-30-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl N2,N6-bis(3,4,5-tris(benzyloxy)benzoyl)-L-lysinate
• CAS: 1446912-30-6
• 化学式: C₆₃H₆₀N₂O₁₀
• 分子量: 1005.18
• InChiKey: FWFGVUSXXKGZOB-XSMLMOGHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.03
• 重原子数：
  75.0
• 可旋转键数：
  27.0
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  139.88
• 氢给体数：
  2.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  methyl N2,N6-bis(3,4,5-tris(benzyloxy)benzoyl)-L-lysinate 在 水 、 sodium hydroxide 作用下， 以 甲醇 为溶剂， 反应 2.0h， 生成 (2S)-2,6-bis[[3,4,5-tris(phenylmethoxy)benzoyl]amino]hexanoic acid
  参考文献：
  名称：

  Design and Synthesis of Novel Janus Dendrimers as Lipophilized Antioxidants

  摘要：

  In the search for better antioxidants with more satisfactory lipophilicity, a series of Janus dendrimers that consisted of gallic acid and alkyl chains as the peripheral groups, were designed and synthesized. These dendrimers take advantage of a dendritic display to carry multi-antioxidants and multi-lipophilic moieties simultaneously. Consequently, the resulting dendrimers, which showed satisfactory lipophilicity and better antioxidant activity than the gallic acid monomer, are potential novel lipophilized antioxidant agents.

  DOI：

  10.1055/s-0032-1318457
• 作为产物：
  描述：

  3,4,5-三苄氧基苯甲酸 、 甲基L-赖氨酸酯盐酸盐(1:1) 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以78%的产率得到methyl N2,N6-bis(3,4,5-tris(benzyloxy)benzoyl)-L-lysinate
  参考文献：
  名称：

  Design and Synthesis of Novel Janus Dendrimers as Lipophilized Antioxidants

  摘要：

  In the search for better antioxidants with more satisfactory lipophilicity, a series of Janus dendrimers that consisted of gallic acid and alkyl chains as the peripheral groups, were designed and synthesized. These dendrimers take advantage of a dendritic display to carry multi-antioxidants and multi-lipophilic moieties simultaneously. Consequently, the resulting dendrimers, which showed satisfactory lipophilicity and better antioxidant activity than the gallic acid monomer, are potential novel lipophilized antioxidant agents.

  DOI：

  10.1055/s-0032-1318457