2,6-Dihydroxy-pyrimidin-4-carbonsaeure-methyl-amid | 1009-04-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2,6-Dihydroxy-pyrimidin-4-carbonsaeure-methyl-amid
• 英文别名: Orotsaeure-methylamid；2,6-dioxo-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid methylamide；N-methyl-2,4-dioxo-1H-pyrimidine-6-carboxamide
• CAS: 1009-04-7
• 化学式: C₆H₇N₃O₃
• mdl: MFCD19595568
• 分子量: 169.14
• InChiKey: JGPCTAKZKFCASV-UHFFFAOYSA-N

物化性质

• 熔点：
  285°C
• 沸点：
  298.41°C (rough estimate)
• 密度：
  1.4623 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  87.3
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• [EN] HETEROBIFUNCTIONAL PAN-SELECTIN ANTAGONISTS HAVING A TRIAZOLE LINKER<br/>[FR] ANTAGONISTES HÉTÉROBIFONCTIONNELS DE PAN-SÉLECTINE PRÉSENTANT UN LIEUR DE TYPE TRIAZOLE
  申请人：GLYCOMIMETICS INC

  公开号：WO2017095904A1

  公开（公告）日：2017-06-08

  Compounds, compositions, and methods for modulating in vitro and in vivo processes mediated by selectin binding. For example, heterobifunctional compounds that inhibit both E-selectins and P-selectins are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids). The compounds are of formula (la) wherein the substituents are as defined in the claims.

  用于调节体外和体内由选择素结合介导的过程的化合物、组合物和方法。例如，描述了抑制E-选择素和P-选择素的异双功能化合物，其中调节选择素的调节剂（例如，抑制或增强）选择素介导功能的包括特定的糖类似物与一类被称为BASAs（苄基氨基磺酸）的化合物结合的成员。这些化合物的化学式为（la），其中取代基如权利要求中所定义。
• PYRIMIDINONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20150065505A1

  公开（公告）日：2015-03-05

  The present invention provides compounds of Formula (I), as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.

  本发明提供了公式（I）所定义的化合物，以及包含任何此类新型化合物的组合物。这些化合物是内皮细胞脂肪酶抑制剂，可用作药物。
• GLYCOMIMETIC INHIBITORS OF THE PA-IL LECTIN, PA-IIL LECTIN OR BOTH THE LECTINS FROM PSEUDOMONAS
  申请人：Magnani John L.

  公开号：US20100041626A1

  公开（公告）日：2010-02-18

  Compositions and methods are provided related to Pseudomonas bacteria. The compositions and methods may be used for diagnosis and therapy of medical conditions involving infection with Pseudomonas bacteria. Such infections include Pseudomonas aeruginosa in the lungs of patients with cystic fibrosis. A compound useful in the present methods may be used in combination with a therapeutic agent or may be linked to a therapeutic agent. Pseudomonas bacteria may be inhibited by blocking colonization, inhibiting virulence factors, arresting growth or killing the bacteria.
• US7517980B2
  申请人：——

  公开号：US7517980B2

  公开（公告）日：2009-04-14
• US8258290B2
  申请人：——

  公开号：US8258290B2

  公开（公告）日：2012-09-04