(Z)-ethyl 2-(1-(4-bromophenylsulfonyl)-4-vinyl-2,5-dihydro-1H-pyrrol-3-yl)-4-phenylbut-3-enoate | 1250283-67-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z)-ethyl 2-(1-(4-bromophenylsulfonyl)-4-vinyl-2,5-dihydro-1H-pyrrol-3-yl)-4-phenylbut-3-enoate
• 英文别名: ethyl (Z)-2-[1-(4-bromophenyl)sulfonyl-4-ethenyl-2,5-dihydropyrrol-3-yl]-4-phenylbut-3-enoate
• CAS: 1250283-67-0
• 化学式: C₂₄H₂₄BrNO₄S
• 分子量: 502.429
• InChiKey: ASCBIIHSVAMQBG-GDNBJRDFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  苯乙烯 、 ethyl 2-((4-bromo-N-(prop-2-ynyl)phenylsulfonamido)methyl)cycloprop-2-enecarboxylate 在 Grubbs catalyst first generation 作用下， 反应 24.0h， 生成 (Z)-ethyl 2-(1-(4-bromophenylsulfonyl)-4-vinyl-2,5-dihydro-1H-pyrrol-3-yl)-4-phenylbut-3-enoate 、 (E)-ethyl 2-(1-(4-bromophenylsulfonyl)-4-vinyl-2,5-dihydro-1H-pyrrol-3-yl)-4-phenylbut-3-enoate
  参考文献：
  名称：

  Ruthenium-Catalyzed Tandem Ring-Opening/Ring-Closing/Cross-Metathesis of 1,6-Cyclopropene-ynes and Olefins for the Construction of the 3-Pyrroline Skeleton

  摘要：

  Catalyzed by the first-generation Grubbs' ruthenium complex, tandem intramolecular/intermolecular metathesis of 1,6-enynes bearing a cyclopropene ring took place smoothly to produce 3-pyrroline derivatives in satisfactory yields via ring-opening/ring-closing/cross-metathesis processes.

  DOI：

  10.1021/ol101455c

文献信息

• Ruthenium-Catalyzed Tandem Ring-Opening/Ring-Closing/Cross-Metathesis of 1,6-Cyclopropene-ynes and Olefins for the Construction of the 3-Pyrroline Skeleton
  作者：Zhi-Bin Zhu、Min Shi

  DOI：10.1021/ol101455c

  日期：2010.10.15

  Catalyzed by the first-generation Grubbs' ruthenium complex, tandem intramolecular/intermolecular metathesis of 1,6-enynes bearing a cyclopropene ring took place smoothly to produce 3-pyrroline derivatives in satisfactory yields via ring-opening/ring-closing/cross-metathesis processes.