4-Aethyl-2-isopropyl-6-methylpyrimidin | 65680-15-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-Aethyl-2-isopropyl-6-methylpyrimidin
• 英文别名: 4-ethyl-2-isopropyl-6-methyl-pyrimidine；4-Ethyl-6-methyl-2-propan-2-ylpyrimidine
• CAS: 65680-15-1
• 化学式: C₁₀H₁₆N₂
• 分子量: 164.25
• InChiKey: UWGFLLYGFLQLJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Substituted Benzamide Compounds
  申请人：Reich Melanie

  公开号：US20120071461A1

  公开（公告）日：2012-03-22

  Substituted benzamide compounds corresponding to formula (I) in which R5, R6, R7, R8, a, b, c, d, t, D and X have defined meanings, a process for their preparation, pharmaceutical compositions comprising such compounds, and a method of using such compounds to treat pain and other conditions mediated at least in part via the bradykinin 1 receptor.

  对应于式(I)的取代苯甲酰胺化合物，其中R5、R6、R7、R8、a、b、c、d、t、D和X具有定义的含义，其制备方法，包括这些化合物的药物组合物，以及使用这些化合物治疗疼痛和其他至少部分通过激肽酶1受体介导的疾病的方法。
• Piperazine Metabotropic Glutamate Receptor 5 (MGLUR5) Negative Allosteric Modulators For Anxiety/Depression
  申请人：Bursavich Matthew Gregory

  公开号：US20090325964A1

  公开（公告）日：2009-12-31

  The present teachings relate to piperazine metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulators having Formula I: wherein the constituent variables are as defined herein. The present teachings further relate to methods for the preparation of the compounds, and to methods for using the compounds for treatment of diseases and disorders including schizophrenia, paranoia, depression, manic-depressive illness and anxiety.

  本发明涉及具有公式I的哌嗪代谢型谷氨酸受体5（mGluR5）负向变构调节剂： 其中，组成变量如本文所定义。本发明还涉及制备该化合物的方法，并涉及使用该化合物治疗疾病和障碍的方法，包括精神分裂症、偏执症、抑郁症、躁郁病和焦虑症。
• Function-based probes for environmental microbiome analysis and methods of making and using the same
  申请人：Battelle Memorial Institute

  公开号：US11169152B2

  公开（公告）日：2021-11-09

  Probe embodiments for identifying analytes involved in biofuel or bioenergy production, bioremediation, or nutrient cycling as well as methods of making and use are described herein. In some embodiments, probes identifying cellulose degradation and/or sugar transport, lignin or chitin degradation, or peptide or toxin metabolism are included. In some embodiments, probes for identifying analytes in a soil sample are included in the compositions and methods disclosed herein.

  本文描述了用于鉴定涉及生物燃料或生物能源生产、生物修复或营养循环的分析物的探针实施方案以及制造和使用方法。在某些实施方案中，包括用于鉴定纤维素降解和/或糖转运、木质素或几丁质降解或肽或毒素代谢的探针。在某些实施方案中，用于鉴定土壤样本中分析物的探针也包含在本文公开的组合物和方法中。
• FUNCTION-BASED PROBES FOR ENVIRONMENTAL MICROBIOME ANALYSIS AND METHODS OF MAKING AND USING THE SAME
  申请人：Battelle Memorial Institute

  公开号：US20190086410A1

  公开（公告）日：2019-03-21

  Probe embodiments for identifying analytes involved in biofuel or bioenergy production, bioremediation, or nutrient cycling as well as methods of making and use are described herein. In some embodiments, probes identifying cellulose degradation and/or sugar transport, lignin or chitin degradation, or peptide or toxin metabolism are included. In some embodiments, probes for identifying analytes in a soil sample are included in the compositions and methods disclosed herein.
• INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
  申请人：ViiV HEALTHCARE UK (NO.5) LIMITED

  公开号：US20200360384A1

  公开（公告）日：2020-11-19

  Compounds of Formula I, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth: