3-氯吡啶甲酰胺盐酸盐 | 1179360-43-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 3-氯吡啶甲酰胺盐酸盐
• 英文名称: 3-chloropyridine-2-carboximidamide hydrochloride
• 英文别名: 3-Chloropicolinimidamide hydrochloride；3-chloropyridine-2-carboximidamide;hydrochloride
• CAS: 1179360-43-0
• 化学式: C₆H₆ClN₃*ClH
• 分子量: 192.048
• InChiKey: OHCTVSVXORSCHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.44
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  62.8
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  ethyl 2-[4-chloro-3-(trifluoromethyl)benzyl]-4,4,4-trifluoro-3-oxobutanoate 、 3-氯吡啶甲酰胺盐酸盐 在 potassium carbonate 作用下， 以 1,4-二氧六环 为溶剂， 反应 1.0h， 以75%的产率得到2-(3-chloropyridin-2-yl)-5-[4-chloro-3-(trifluoromethyl)benzyl]-6-(trifluoromethyl)pyrimidin-4(3H)-one
  参考文献：
  名称：

  TW2016/5831

  摘要：

  公开号：

文献信息

• HETEROCYCLIC SUBSTITUTED TRIFLUOROMETHYL PYRIMIDINONES AND THEIR USE
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20160237059A1

  公开（公告）日：2016-08-18

  The present application relates to novel heterocyclically substituted 6-(trifluoromethyl)pyrimidin-4(3H)-one derivatives, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of cardiovascular, renal, inflammatory and fibrotic diseases.

  本申请涉及新颖的杂环取代的6-(三氟甲基)嘧啶-4(3H)-酮衍生物，其制备方法，它们单独或组合用于治疗和/或预防疾病，以及它们用于制备用于治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管、肾脏、炎症和纤维化疾病。
• 2-Heteroaryl-imidazotriazinones and their use in the treatment of inflammatory or immune diseases
  申请人：Alonso-Alija Cristina

  公开号：US20060293326A1

  公开（公告）日：2006-12-28

  The invention relates to 2-Heteroaryl-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases. The present invention relates to compounds of the general formula (I) in which R 1 denotes 5- to 10-membered heteroaryl, which is optionally substituted by identical or different residues selected from the group consisting of halogen, (C 1 -C 4 )-alkyl, trifluoromthyl, cyano, nitro und trifluoromethoxy, denotes 3- to 10-membered carbocyclyl or carbon-bonded, 4- to 10-membered heterocyclyl, whereby carbocyclyl and heterocyclyl are optionally substituted by identical or different residues selected from the group consisting of (C 1 -C 6 )-aldyl, (C 1 -C 6 )-aldoxy, hydroxy, halogen, trifluoromethyl and oxo, or denotes (C 2 -C 10 )-alkyl, which is optionally substituted by identical or different residues selected from the group the group consisting of (C 1 -C 6 )-alkoxy, hydroxy, halogen, 3- to 10-membered carbocyclyl and oxo.

  本发明涉及2-杂环芳基咪唑三嗪酮的制备方法及其在药物中的应用，特别是用于治疗和/或预防炎症过程和/或免疫性疾病。本发明涉及通式（I）的化合物，其中R1表示5-至10-成员杂环芳基，该杂环芳基可以被选自卤素，（C1-C4）-烷基，三氟甲基，氰基，硝基和三氟甲氧基的相同或不同残基取代，或表示3-至10-成员碳环烷基或碳键结合的4-至10-成员杂环烷基，其中碳环烷基和杂环烷基可以被选自（C1-C6）-醛基，（C1-C6）-醛氧基，羟基，卤素，三氟甲基和氧代物的相同或不同残基取代，或表示（C2-C10）-烷基，该烷基可以被选自（C1-C6）-氧烷基，羟基，卤素，3-至10-成员碳环烷基和氧代物的相同或不同残基取代。
• 2-HETEROARYL-IMIDAZOTRIAZINONES AND THEIR USE IN THE TREATMENT OF INFLAMMATORY OR IMMUNE DISEASES
  申请人：Bayer HealthCare AG

  公开号：EP1399439A1

  公开（公告）日：2004-03-24
• USE OF A COMPOSITION COMPRISING METAL COMPLEX COMPOUNDS AND POLYPHOSPHONATES AS CATALYSTS FOR OXIDATIONS
  申请人：Ciba Specialty Chemicals Holding Inc.

  公开号：EP1703977A1

  公开（公告）日：2006-09-27
• [EN] 2-HETEROARYL-IMIDAZOTRIAZINONES AND THEIR USE IN THE TREATMENT OF INFLAMMATORY OR IMMUNE DISEASES<br/>[FR] 2-HETEROARYL-IMIDAZOTRIAZINONES ET UTILISATION DANS LE TRAITEMENT DE MALADIES INFLAMMATOIRES OU IMMUNITAIRES
  申请人：BAYER AG

  公开号：WO2002098873A1

  公开（公告）日：2002-12-12

  The invention relates to 2-Heteroaryl-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases. The present invention relates to compounds of the general formula (I) in which R1 denotes 5- to 10- membered heteroaryl, which is optionally substituted by identical or different residues selected from the group consisting of halogen, (C¿1?-C4)-alkyl, trifluoromthyl, cyano, nitro und trifluoromethoxy, denotes 3-to 10-membered carbocyclyl or carbon-bonded, 4- to 10-membered heterocyclyl, whereby carbocyclyl and heterocyclyl are optionally substituted by identical or different residues selected from the group consisting of (C1-C6)-aldyl, (C1-C6)-aldoxy, hydroxy, halogen, trifluoromethyl and oxo, or denotes (C2-C10)-alkyl, which is optionally substituted by identical or different residues selected from the group the group consisting of (C1-C6)-alkoxy, hydroxy, halogen, 3-to 10-membered carbocyclyl and oxo.