癸酸(2-羟基亚苄基)酰肼 | 101739-63-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 癸酸(2-羟基亚苄基)酰肼
• 英文名称: decanoic acid (2-hydroxybenzylidene)hydrazide
• 英文别名: Salicylaldehyd-caprinylhydrazon；N-[(2-hydroxyphenyl)methylideneamino]decanamide
• CAS: 101739-63-3
• 化学式: C₁₇H₂₆N₂O₂
• 分子量: 290.406
• InChiKey: MNLRFEJBPGQQGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  21
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  61.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  癸酸(2-羟基亚苄基)酰肼 在 甲酸 作用下， 反应 0.05h， 以79%的产率得到5-(2-Hydroxyphenyl)-4-octyl-1,2-dihydropyrazol-3-one
  参考文献：
  名称：

  Kidwai; Bhushan; Misra, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2000, vol. 39, # 6, p. 458 - 461

  摘要：

  DOI：
• 作为产物：
  描述：

  癸酸甲酯 在 一水合肼 、 溶剂黄146 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 5.0h， 生成 癸酸(2-羟基亚苄基)酰肼
  参考文献：
  名称：

  Thiazolidin-4-one and hydrazone derivatives of capric acid as possible anti-inflammatory, analgesic and hydrogen peroxide-scavenging agents

  摘要：

  Starting from capric acid, hydrazone and thiazolidin-4-one derivatives have been synthesized in the present investigation. Decanoic acid hydrazide was reacted appropriately to yield hydrazones, which were then cyclized to yield the corresponding thiazolidin-4-ones. The structures of the newly synthesized compounds were confirmed by analytical and spectral methods. Anti-inflammatory, analgesic, and hydrogen peroxide-scavenging activity of the title compounds were evaluated. Among synthesized compounds, 2-hydroxyphenyl thiazolidinone with 44.90% inhibition of inflammation was the most potent anti-inflammatory agent. Similarly, 4-methoxybenzylidine hydrazide with 64.90% inhibition of writhing was observed to be the most potent analgesic agent of the synthesized compounds. All the synthesized compounds exhibited potent hydrogen peroxide-scavenging activity.

  DOI：

  10.3109/14756366.2010.535796

文献信息

• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Cu: MVol.B4, 170, page 1824 - 1825
  作者：

  DOI：——

  日期：——
• Ohta, H., Bulletin of the Chemical Society of Japan, 1960, vol. 33, p. 202 - 205
  作者：Ohta, H.

  DOI：——

  日期：——