(1R,2R)-N,N'-bis[(R)-phenyl(2-hydroxy-3,5-di-tert-butylbenzyl)]cyclohexane-1,2-diamine | 1251855-71-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1R,2R)-N,N'-bis[(R)-phenyl(2-hydroxy-3,5-di-tert-butylbenzyl)]cyclohexane-1,2-diamine
• 英文别名: 2,4-ditert-butyl-6-[(R)-[[(1R,2R)-2-[[(R)-(3,5-ditert-butyl-2-hydroxyphenyl)-phenylmethyl]amino]cyclohexyl]amino]-phenylmethyl]phenol
• CAS: 1251855-71-6
• 化学式: C₄₈H₆₆N₂O₂
• 分子量: 703.064
• InChiKey: GUMOJVFPBLZHKZ-BMGLKWEPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.1
• 重原子数：
  52
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  64.5
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (R,R)-N,N'-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediamine 、 苯基溴化镁 在 氯化铵 作用下， 以 乙醚 为溶剂， 以76%的产率得到(1R,2R)-N,N'-bis[(R)-phenyl(2-hydroxy-3,5-di-tert-butylbenzyl)]cyclohexane-1,2-diamine
  参考文献：
  名称：

  The synthesis of novel tetradentate ligands derived from salen and their application in enantioselective silylcyanation of aldehydes

  摘要：

  Two new tetradentate ligands derived from salen have been prepared and their titanium complexes are used as chiral catalysts in the enantioselective silylcyanation of aldehydes, which give the silyl ethers of cyanohydrins in moderate to good enantiomeric excesses. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.05.050

文献信息

• The synthesis of novel tetradentate ligands derived from salen and their application in enantioselective silylcyanation of aldehydes
  作者：Chengwei Lv、Mei Wu、Shoufeng Wang、Chungu Xia、Wei Sun

  DOI：10.1016/j.tetasy.2010.05.050

  日期：2010.8

  Two new tetradentate ligands derived from salen have been prepared and their titanium complexes are used as chiral catalysts in the enantioselective silylcyanation of aldehydes, which give the silyl ethers of cyanohydrins in moderate to good enantiomeric excesses. (C) 2010 Elsevier Ltd. All rights reserved.