3-(β-Acetylphenaethyl)-4-hydroxy-cumarin | 10366-62-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 3-(β-Acetylphenaethyl)-4-hydroxy-cumarin
• 英文别名: 4-Hydroxy-3-(3-oxo-2-phenylbutyl)chromen-2-one
• CAS: 10366-62-8
• 化学式: C₁₉H₁₆O₄
• 分子量: 308.334
• InChiKey: KIWOOMILCAEKFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Genetic variants of VKORC1 predicting warfarin sensitivity
  申请人：Academia Sinica

  公开号：EP2246445A1

  公开（公告）日：2010-11-03

  We discovered that a polymorphism in the promoter of the VKORCI gene is associated with warfarin sensitivity. This polymorphism can explain both the interindividual and inter-ethnic differences in warfarin dose requirements. Furthermore, the polymorphism is also associated with promoter activity. Thus, the promoter sequence or activity of the VKORCI gene of a subject can be used to predict how much warfarin should be prescribed for the subject. Relevant methods and compositions are provided.

  我们发现，VKORCI 基因启动子上的多态性与华法林敏感性有关。这种多态性可以解释华法林剂量需求的个体间和种族间差异。此外，该多态性还与启动子活性有关。因此，受试者 VKORCI 基因的启动子序列或活性可用来预测该受试者应服用多少华法林。本文提供了相关的方法和组合物。
• Enhancing the toxicity of warfarin in rodents
  申请人：Reckitt Benckiser Inc., Delaware corporation

  公开号：US20010041737A1

  公开（公告）日：2001-11-15

  The presence of a small amount of an antibiotic, such as metronidazole or a salt or derivative thereof, in warfarin-containing rodent baits enhances the toxicity of warfarin against rodents which have heretofore shown apparent resistance to warfarin.

  在含有华法林的啮齿动物毒饵中加入少量抗生素，如甲硝唑或其盐或衍生物，可增强华法林对啮齿动物的毒性，而啮齿动物迄今对华法林已表现出明显的抗药性。
• Genetic variants predicting warfarin sensitivity
  申请人：Chen Yuan-Tsong

  公开号：US20060166239A1

  公开（公告）日：2006-07-27

  We discovered that a polymorphism in the promoter of the VKORC1 gene is associated with warfarin sensitivity. This polymorphism can explain both the inter-individual and inter-ethnic differences in warfarin dose requirements. Furthermore, the polymorphism is also associated with promoter activity. Thus, the promoter sequence or activity of the VKORC1 gene of a subject can be used to predict how much warfarin should be prescribed for the subject. Relevant methods and compositions are provided.

  我们发现，VKORC1 基因启动子上的多态性与华法林敏感性有关。这种多态性可以解释华法林剂量需求的个体间和种族间差异。此外，该多态性还与启动子活性有关。因此，受试者 VKORC1 基因的启动子序列或活性可用来预测该受试者应服用多少华法林。本文提供了相关的方法和组合物。
• 4-HYDROXY-BENZOPYRAN-2-ONES AND 4-HYDROXY-CYCLOALKYL B]PYRAN-2-ONES USEFUL TO TREAT RETROVIRAL INFECTIONS
  申请人：THE UPJOHN COMPANY

  公开号：EP0682663A1

  公开（公告）日：1995-11-22
• PYRANONE COMPOUNDS USEFUL TO TREAT RETROVIRAL INFECTIONS
  申请人：PHARMACIA & UPJOHN COMPANY

  公开号：EP0758327A1

  公开（公告）日：1997-02-19