N-((2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)methyl)cyclohexanecarboxamide | 1357104-22-3

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 哈马拉生物碱
• 英文名称: N-((2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)methyl)cyclohexanecarboxamide
• CAS: 1357104-22-3
• 化学式: C₁₉H₂₅N₃O
• 分子量: 311.427
• InChiKey: QHWBDFNMEAFNPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.05
• 重原子数：
  23.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  56.92
• 氢给体数：
  3.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  N-((2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)methyl)cyclohexanecarboxamide 在 potassium hydroxide 、 sodium hydroxide 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 反应 3.5h， 生成 12-benzyl-2-(cyclohexylcarbonyl)-1,2,3,4,6,7,12,12b-octahydropyrazino[2,1-a]β-carbolin-4-one
  参考文献：
  名称：

  Synthesis of new praziquantel analogues: Potential candidates for the treatment of schistosomiasis

  摘要：

  An efficient synthesis of antischistosomal drug praziquantel and analogues was achieved and the synthetic route designed was to afford structurally diverse analogues for better structure-activity relationship understanding. Total of nineteen PZQ analogues with structural variations at amide, piperazine and aromatic moieties have been synthesized and fully characterized. Among all the new analogues tested for antischistosomal activity, one dimethoxy tetrahydroisoquinoline analogue and two tetrahydro-beta-carboline analogues exhibited moderate activity against adult Schistosoma mansoni. Tetrahydro-beta-carboline analogues showed moderate activity whereas the presence of p-trifluoromethylbenzoyl and p-toluenesulphonyl moieties resulted in complete suppression of antischistosomal activity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.11.108
• 作为产物：
  描述：

  tert-butyl 1-(cyclohexanecarboxamidomethyl)-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indole-2-carboxylate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 N-((2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)methyl)cyclohexanecarboxamide
  参考文献：
  名称：

  Synthesis of new praziquantel analogues: Potential candidates for the treatment of schistosomiasis

  摘要：

  An efficient synthesis of antischistosomal drug praziquantel and analogues was achieved and the synthetic route designed was to afford structurally diverse analogues for better structure-activity relationship understanding. Total of nineteen PZQ analogues with structural variations at amide, piperazine and aromatic moieties have been synthesized and fully characterized. Among all the new analogues tested for antischistosomal activity, one dimethoxy tetrahydroisoquinoline analogue and two tetrahydro-beta-carboline analogues exhibited moderate activity against adult Schistosoma mansoni. Tetrahydro-beta-carboline analogues showed moderate activity whereas the presence of p-trifluoromethylbenzoyl and p-toluenesulphonyl moieties resulted in complete suppression of antischistosomal activity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.11.108