1,3-bis-(2-chloro-ethylsulfanyl)-butane | 63732-11-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 1,3-bis-(2-chloro-ethylsulfanyl)-butane
• 英文别名: 1,3-Bis-(2-chlor-aethylmercapto)-butan；1,3-Bis(2-chloroethylsulfanyl)butane
• CAS: 63732-11-6
• 化学式: C₈H₁₆Cl₂S₂
• 分子量: 247.253
• InChiKey: SJGPIQSFESQEHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  12
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  50.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氯化亚砜 、 乙醚 作用下， 生成 1,3-bis-(2-chloro-ethylsulfanyl)-butane
  参考文献：
  名称：

  双（2-氯乙基巯基）-烷烃。

  摘要：

  DOI：

  10.1021/ja01197a055

文献信息

• Multi-organ media compositions and methods of their use
  申请人：Los Alamos National Security, LLC

  公开号：US10564148B2

  公开（公告）日：2020-02-18

  Disclosed herein are media for culture of cells, tissues, and/or organs. The media formulations disclosed herein can be used to support growth, viability, and/or function of one or more than one cell type, tissue, or organ. In some embodiments, one or more cell types, tissues, organ devices, and/or organs are contacted with a disclosed culture medium under conditions sufficient to support growth, viability, and/or function of the cell types, tissues, and/or organs. The disclosed media can be used in methods of culturing multiple cell types, and in some examples, is used in a platform device including one or more organ devices, for example, by circulating the medium through the one or more organ devices in the platform.

  本文公开的是用于培养细胞、组织和/或器官的培养基。本文公开的培养基配方可用于支持一种或多种细胞类型、组织或器官的生长、活力和/或功能。在某些实施方案中，一种或多种细胞类型、组织、器官装置和/或器官在足以支持细胞类型、组织和/或器官生长、存活和/或功能的条件下与所公开的培养基接触。所公开的培养基可用于多种细胞类型的培养方法，在某些实例中，可用于包括一个或多个器官装置的平台装置中，例如，通过在平台中的一个或多个器官装置中循环培养基。
• Bio-assessment device and method of making the device
  申请人：Triad National Security, LLC

  公开号：US10634665B2

  公开（公告）日：2020-04-28

  Disclosed herein are embodiments of a device that can be used to mimic the biochemical and physiological actions of a lung organ. Also disclosed herein are embodiments of components that are included in the device as well as methods of making and using the device. Further disclosed are platform device embodiments and various components used therein that can be used in combination with the lung organ devices disclosed herein. In some embodiments, the disclosed devices can be used to determine drug toxicity and also can be used with one or more disease models to determine methods of treating disease.

  本文公开了一种可用于模拟肺器官的生化和生理作用的装置的实施例。本文还公开了包括在该装置中的组件的实施例以及制造和使用该装置的方法。进一步公开的是可与本文公开的肺器官装置结合使用的平台装置实施例及其所用的各种组件。在某些实施例中，所公开的装置可用于确定药物毒性，也可与一种或多种疾病模型一起用于确定治疗疾病的方法。
• MULTI-ORGAN MEDIA COMPOSITIONS AND METHODS OF THEIR USE
  申请人：Los Alamos National Security, LLC

  公开号：US20170275587A1

  公开（公告）日：2017-09-28

  Disclosed herein are media for culture of cells, tissues, and/or organs. The media formulations disclosed herein can be used to support growth, viability, and/or function of one or more than one cell type, tissue, or organ. In some embodiments, one or more cell types, tissues, organ devices, and/or organs are contacted with a disclosed culture medium under conditions sufficient to support growth, viability, and/or function of the cell types, tissues, and/or organs. The disclosed media can be used in methods of culturing multiple cell types, and in some examples, is used in a platform device including one or more organ devices, for example, by circulating the medium through the one or more organ devices in the platform.
• BIO-ASSESSMENT DEVICE AND METHOD OF MAKING THE DEVICE
  申请人：Los Alamos National Security, LLC

  公开号：US20170307594A1

  公开（公告）日：2017-10-26

  Disclosed herein are embodiments of a device that can be used to mimic the biochemical and physiological actions of a lung organ. Also disclosed herein are embodiments of components that are included in the device as well as methods of making and using the device. Further disclosed are platform device embodiments and various components used therein that can be used in combination with the lung organ devices disclosed herein. In some embodiments, the disclosed devices can be used to determine drug toxicity and also can be used with one or more disease models to determine methods of treating disease.
• [EN] BIO-ASSESSMENT DEVICE AND METHOD OF MAKING THE DEVICE<br/>[FR] DISPOSITIF D'ÉVALUATION BIOLOGIQUE ET PROCÉDÉ DE FABRICATION DU DISPOSITIF
  申请人：LOS ALAMOS NAT SECURITY LLC

  公开号：WO2016049363A1

  公开（公告）日：2016-03-31

  Disclosed herein are embodiments of a device that can be used to mimic the biochemical and physiological actions of a lung organ. Also disclosed herein are embodiments of components that are included in the device as well as methods of making and using the device. Further disclosed are platform device embodiments and various components used therein that can be used in combination with the lung organ devices disclosed herein. In some embodiments, the disclosed devices can be used to determine drug toxicity and also can be used with one or more disease models to determine methods of treating disease.