(+)-4-Hydroxy-7-oxo-3-methoxy-17-methylmorphinan | 73079-30-8

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: (+)-4-Hydroxy-7-oxo-3-methoxy-17-methylmorphinan
• 英文别名: ent-4-hydroxy-3-methoxy-17-methyl-morphinan-7-one；ent-4-Hydroxy-3-methoxy-17-methyl-morphinan-7-on
• CAS: 73079-30-8
• 化学式: C₁₈H₂₃NO₃
• 分子量: 301.386
• InChiKey: WYJYLDLCYXZDMQ-GLJUWKHASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.27
• 重原子数：
  22.0
• 可旋转键数：
  1.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  49.77
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydroxide 、 sodium amalgam 作用下， 生成 (+)-4-Hydroxy-7-oxo-3-methoxy-17-methylmorphinan
  参考文献：
  名称：

  Liquid–liquid phase separation and crystallization behavior of poly(ethylene terephthalate)/poly(ether imide) blend

  摘要：

  The liquid-liquid (L-L) phase separation and crystallization behavior of poly(ethylene terephthalate) (PET)/poly(ether imide) (PEI) blend were investigated with optical microscopy, light scattering, and small angle X-ray scattering (SAXS). The thermal analysis showed that the concentration fluctuation between separated phases was controllable by changing the time spent for demixing before crystallization. The L-L phase-separated specimens at 130 C for various time periods were subjected to a temperature-jump of 180 C for the isothermal crystallization and then effects of L-L phase separation on crystallization were investigated. The crystal growth rate decreased with increasing L-L phase-separated time (t(s)). The slow crystallization for a long t(s) implied that the growth path of crystals was highly distorted by the rearrangement of the spinodal domains associated with coarsening. The characteristic morphological parameters at the lamellar level were determined by the correlation function analysis on the SAXS data. The blend had a larger amorphous layer thickness than the pure PET, indicating that PEI molecules in the PET-rich phase were incorporated into the interlamellar regions during crystallization. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0032-3861(02)00054-x

文献信息

• Studies in the (+)-morphinan series. 7. Unusual crystallographic and tautomeric properties of (+)-4-hydroxy-7-oxo-3-methoxy-17-methyl-5,6-dehydromorphinan: an interlacing double helix
  作者：Junichi Minamikawa、Kenner C. Rice、Arthur E. Jacobson、Arnold Brossi、Thomas H. Williams、J. V. Silverton

  DOI：10.1021/jo01298a028

  日期：1980.5
• Studies on Sinomenine. LXI. On (+)-epi-Dihydro-thebainone
  作者：Kakuji Goto、Kimiyo Michi

  DOI：10.1246/bcsj.22.262

  日期：1949.6