Calcimimetic B | 1067194-86-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Calcimimetic B
• 英文别名: (R)-1-(6-methoxy-4''-(trifluoromethyl)biphenyl-3-yl)-N-((R)-1-phenylethyl)ethanamine；(1R)-N-[(1R)-1-[4-methoxy-3-[4-(trifluoromethyl)phenyl]phenyl]ethyl]-1-phenylethanamine
• CAS: 1067194-86-8
• 化学式: C₂₄H₂₄F₃NO
• 分子量: 399.456
• InChiKey: ZQLAZWPQJIPJAJ-IAGOWNOFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  C₁₆H₁₃F₃O₂ 、 R(+)-alpha-甲基苄胺 在 四氯化钛 、 sodium tetrahydroborate 作用下， 以 二氯甲烷 、 甲醇 为溶剂， 生成 (1R)-N-[(1S)-1-[4-methoxy-3-[4-(trifluoromethyl)phenyl]phenyl]ethyl]-1-phenylethanamine 、 Calcimimetic B
  参考文献：
  名称：

  含有二苄胺核心的钙敏感受体的口服有效正变构调节剂的发现

  摘要：

  本文描述了由先导化合物1开发的一系列新颖且口服有效的II型拟钙剂的发现。当在大鼠药效学模型中口服给药时，化合物22相对于运载体抑制血浆PTH水平。

  DOI：

  10.1016/j.bmcl.2010.07.060

文献信息

• STABLE EMULSION FORMULATIONS
  申请人：Gore Anuradha

  公开号：US20070249520A1

  公开（公告）日：2007-10-25

  The present invention relates to injectable formulations of irritant agents, such as calcimimetics, that are pharmaceutically stable and demonstrate a reduced incidence of irritation, pain, phlebitis, precipitation and hemolysis upon injection.
• METHODS FOR TREATING CYSTIC KIDNEY DISEASE
  申请人：Moe Sharon

  公开号：US20080027052A1

  公开（公告）日：2008-01-31

  The present invention relates to methods for treating or preventing cystic kidney diseases or disorders using calcimimetics and pharmaceutically acceptable salts of these compounds. Various aspects related to treating mammal including humans. Still other aspects related to various formulations including combination formulation that may be used to treat kidney disease and to treat or prevent other pathologies such as pain, hypertension, water retention, infection, and the like.
• Methods of treating bowel disorders
  申请人：Geibel John Peter

  公开号：US20090018135A1

  公开（公告）日：2009-01-15

  The present invention relates to methods for treating or preventing bowel disorders using calcimimetics.
• CALCIMIMETIC COMPOUND FOR USE IN THE TREATMENT OF EPITHELIAL INJURY
  申请人：Geibel John Peter

  公开号：US20110144102A1

  公开（公告）日：2011-06-16

  This invention relates generally to the field of medicine and, more specifically, to methods for treating epithelial injury, in particular, due to ischemia, hypoxia, trauma, chemolytics or radiation exposure.
• METHODS OF TREATING HYPERACIDIC DISORDERS
  申请人：Geibel John Peter

  公开号：US20120232158A1

  公开（公告）日：2012-09-13

  The present invention relates to methods for treating or preventing hyperacidic disorders such as GERD or NERD using calcium receptor active compounds.