2-[2,6-dichloro-3-[(2,2-dimethylpropanoylamino)methyl]anilino]-6-(3,3-difluoropyrrolidin-1-yl)-1-methyl-N-(2,2,3,3,3-pentafluoropropyl)benzimidazole-5-carboxamide | 1380832-32-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-[2,6-dichloro-3-[(2,2-dimethylpropanoylamino)methyl]anilino]-6-(3,3-difluoropyrrolidin-1-yl)-1-methyl-N-(2,2,3,3,3-pentafluoropropyl)benzimidazole-5-carboxamide
• CAS: 1380832-32-5
• 化学式: C₂₈H₂₉Cl₂F₇N₆O₂
• 分子量: 685.472
• InChiKey: XMRAWNGXDAEMKL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  45
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  91.3
• 氢给体数：
  3
• 氢受体数：
  12

文献信息

• [EN] 6-AMINO-2-PHENYLAMINO-1H-BENZIMIDAZOLE-5-CARBOXAMIDE- DERIVATIVES AND THEIR USE AS MICROSOMAL PROSTAGLANDIN E2 SYNTHASE-1 INHIBITORS<br/>[FR] DÉRIVÉS DE 6 -AMINO- 2 - PHÉNYLAMINO- 1H-BENZIMIDAZOLE- 5 -CARBOXAMIDE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE LA PROSTAGLANDINE E2 SYNTHASE-1 MICROSOMALE
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2012076673A1

  公开（公告）日：2012-06-14

  This invention relates to compounds of formula (I) their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, L, M, W, R1, R2, R3, R4, R6, R7, R9, Ra, Rb have meanings given in the description.

  这项发明涉及式(I)的化合物，它们作为微粒体前列腺素E2合酶-1(mPGES-1)的抑制剂的用途，含有它们的药物组合物，以及它们作为治疗和/或预防炎症性疾病和相关症状的药物的用途。A、L、M、W、R1、R2、R3、R4、R6、R7、R9、Ra、Rb在描述中有给定的含义。
• NOVEL COMPOUNDS
  申请人：PRIEPKE Henning

  公开号：US20120149676A1

  公开（公告）日：2012-06-14

  This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin E 2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, L, M, W, R 1 , R 2 , R 3 , R 4 , R 6 , R 7 , R 9 , R a , R b have meanings given in the description.

  这项发明涉及到式I的化合物，它们作为微粒体前列腺素E2合酶-1（mPGES-1）的抑制剂的用途，含有它们的药物组合物，以及它们作为治疗和/或预防炎症性疾病和相关症状的药物的用途。A、L、M、W、R1、R2、R3、R4、R6、R7、R9、Ra、Rb在描述中有给出含义。
• US8674113B2
  申请人：——

  公开号：US8674113B2

  公开（公告）日：2014-03-18