ethanone, 2-[5-fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methyIene]-1H-inden-3-yl]-1-(4-methylpiperazinyl) | 944159-26-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 英文名称: ethanone, 2-[5-fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methyIene]-1H-inden-3-yl]-1-(4-methylpiperazinyl)
• 英文别名: 2-[(3Z)-6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]-1-(4-methylpiperazin-1-yl)ethanone
• CAS: 944159-26-6
• 化学式: C₂₅H₂₇FN₂O₂S
• 分子量: 438.566
• InChiKey: BCJQQASSQIXTTJ-HMAPJEAMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  59.8
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Derivatives of sulindac, use thereof and preparation thereof
  申请人：Piazza Gary

  公开号：US20070244122A1

  公开（公告）日：2007-10-18

  Derivatives of sulindac are provided along with pharmaceutical compositions containing them and use for precancerous conditions and treating cancer. Derivatives of sulindac are also suitable for treating chronic inflammatory conditions. A method for preparing the derivatives is also provided.
• US8044048B2
  申请人：——

  公开号：US8044048B2

  公开（公告）日：2011-10-25