8-Amino-5-sulfo-7-phenylpyrido[3,4-d]pyridazine-1,4(2H,3H)dione | 143324-06-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 8-Amino-5-sulfo-7-phenylpyrido[3,4-d]pyridazine-1,4(2H,3H)dione
• 英文别名: 8-Amino-1,4-dioxo-7-phenyl-2,3-dihydropyrido[3,4-d]pyridazine-5-sulfonic acid
• CAS: 143324-06-5
• 化学式: C₁₃H₁₀N₄O₅S
• 分子量: 334.312
• InChiKey: RAWGYTSPFQIEGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  160
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• Pyridopyridazine compounds and their use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0491477A1

  公开（公告）日：1992-06-24

  An assay method which comprises utilizing chemiluminescence of a pyridopyridazine compound of the formula wherein R₁ is a hydrocarbon group or a heterocyclic group each of which may be substituted and R₂ is hydroxy group, thiol group, amino group or a monosubstituted amino group, and when R₂ is a monosubstituted amino group, R₂ may be taken together with R₁ to form the ring; R₃ is hydrogen atom, a hydroxy group which may be substituted, an amino group which may be substituted, a thiol group which may be substituted, a halogen atom, a heterocyclic group, nitro group, cyano group, carboxyl group which may be esterified or amidated, azido group, sulfo group or an organic sulfonyl group, provided that when R₁ is an aliphalic group, R₃ is not hydrogen atom; and X is oxygen atom or sulfur atom,or a salt thereof; and a novel compound of the formula (I) wherein the symbols are as defined above with proviso that when R₃ is a hydrogen atom, R₁ is a substituted aryl group or a heterocyclic group which may be substituted,or a salt thereof and the production methods thereof.

  一种检测方法，包括利用化学发光法检测式中的哒嗪化合物 其中 R₁ 是烃基或杂环基，每个烃基或杂环基均可被取代，R₂ 是羟基、硫醇基、氨基或单取代氨基，当 R₂ 是单取代氨基时，R₂ 可与 R₁ 一起形成环；R₃ 是氢原子、可被取代的羟基、可被取代的氨基、可被取代的硫醇基、卤素原子、杂环基、硝基、氰基、可被酯化或酰胺化的羧基、叠氮基、磺基或有机磺酰基，但当 R₁ 是脂环族基团时，R₃ 不是氢原子；和 X 是氧原子或硫原子，或其盐类；以及式（I）的新型化合物，其中符号如上定义，但当 R₃ 是氢原子时，R₁ 是取代的芳基或可被取代的杂环基团，或其盐类及其生产方法。
• US5420275A
  申请人：——

  公开号：US5420275A

  公开（公告）日：1995-05-30