N-(3-chlorophenethyl)-N'-cyclohexyl-pyrimidin-2,4,6-(1H,3H,5H)-trione | 1391385-48-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-(3-chlorophenethyl)-N'-cyclohexyl-pyrimidin-2,4,6-(1H,3H,5H)-trione
• 英文别名: 1-(3-Chlorophenethyl)-3-cyclohexylpyrimidine-2,4,6-(1H,3H,5H)-trione；1-[2-(3-chlorophenyl)ethyl]-3-cyclohexyl-1,3-diazinane-2,4,6-trione
• CAS: 1391385-48-0
• 化学式: C₁₈H₂₁ClN₂O₃
• 分子量: 348.829
• InChiKey: QVHVGGZKGJPSNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  57.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] SELECTIVE CALCIUM CHANNEL ANTAGONISTS<br/>[FR] ANTAGONISTES SÉLECTIFS DES CANAUX CALCIQUES
  申请人：UNIV NORTHWESTERN

  公开号：WO2012100073A1

  公开（公告）日：2012-07-26

  The present invention relates to compositions and methods for the treatment and/or prevention of neurodegenerative disorders, e.g., Parkinson's disease (PD). In particular, the present invention provides compositions comprising selective antagonists of calcium ion channels (e.g., cav 1.3 -type ion channels), and methods of use thereof to treat or prevent neurodegenerative disorders.

  本发明涉及用于治疗和/或预防神经退行性疾病，例如帕金森病（PD）的组合物和方法。具体地，本发明提供包含钙离子通道的选择性拮抗剂（例如，cav 1.3型离子通道）的组合物，以及利用这些方法来治疗或预防神经退行性疾病。
• Selective calcium channel antagonists
  申请人：Northwestern University

  公开号：US10105366B2

  公开（公告）日：2018-10-23

  The present invention relates to compositions and methods for the treatment and/or prevention of neurodegenerative disorders, e.g., Parkinson's disease (PD). In particular, the present invention provides compositions comprising selective antagonists of calcium ion channels (e.g., cav1.3-type ion channels), and methods of use thereof to treat or prevent neurodegenerative disorders.

  本发明涉及治疗和/或预防神经退行性疾病（如帕金森病（PD））的组合物和方法。特别是，本发明提供了包含钙离子通道（如cav1.3型离子通道）选择性拮抗剂的组合物及其用于治疗或预防神经退行性疾病的方法。
• SELECTIVE CALCIUM CHANNEL ANTAGONISTS
  申请人：Surmeier, JR. Dalton J.

  公开号：US20120196883A1

  公开（公告）日：2012-08-02

  The present invention relates to compositions and methods for the treatment and/or prevention of neurodegenerative disorders, e.g., Parkinson's disease (PD). In particular, the present invention provides compositions comprising selective antagonists of calcium ion channels (e.g., cav1.3-type ion channels), and methods of use thereof to treat or prevent neurodegenerative disorders.
• US9428467B2
  申请人：——

  公开号：US9428467B2

  公开（公告）日：2016-08-30