2'-O-methyl-2,5'-anhydrouridine | 175471-64-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2'-O-methyl-2,5'-anhydrouridine
• 英文别名: (6R,7R,8R,9R)-8-Hydroxy-7-methoxy-7,8,9,10-tetrahydro-6,9-epoxypyrimido[2,1-b][1,3]oxazocin-2(6H)-one；(1R,10R,11R,12R)-11-hydroxy-12-methoxy-8,13-dioxa-2,6-diazatricyclo[8.2.1.02,7]trideca-3,6-dien-5-one
• CAS: 175471-64-4
• 化学式: C₁₀H₁₂N₂O₅
• 分子量: 240.216
• InChiKey: SNEKINQEWXDGCE-ZOQUXTDFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  80.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2'-O-methyl-2,5'-anhydrouridine 在 氨 作用下， 以 甲醇 为溶剂， 反应 120.0h， 以85%的产率得到2'-O-methylisocytidine
  参考文献：
  名称：

  Syntheses of 2′-O-Methylisocytidine Phosphoramidite and Methylphosphonamidite Synthons

  摘要：

  The 2'-O-methylisocytidine phosphoramidite synthon 7 and methylphosphonamidite synthon 8 are synthesized from 2'-O-methyluridine. The N-2-(N',N'-dimethylformamidine) protected 2'-O-methylisocytidine is stable to basic deamination and acidic depyrimidination. Synthon 7 and synthon 8 have been incorporated into oligomers via the automated solid state procedure.

  DOI：

  10.1080/07328319608002392
• 作为产物：
  描述：

  2'-O-methyl-5'-O-p-tolylsulfonyluridine 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 乙腈 为溶剂， 反应 48.0h， 以61%的产率得到2'-O-methyl-2,5'-anhydrouridine
  参考文献：
  名称：

  Syntheses of 2′-O-Methylisocytidine Phosphoramidite and Methylphosphonamidite Synthons

  摘要：

  The 2'-O-methylisocytidine phosphoramidite synthon 7 and methylphosphonamidite synthon 8 are synthesized from 2'-O-methyluridine. The N-2-(N',N'-dimethylformamidine) protected 2'-O-methylisocytidine is stable to basic deamination and acidic depyrimidination. Synthon 7 and synthon 8 have been incorporated into oligomers via the automated solid state procedure.

  DOI：

  10.1080/07328319608002392