2-[2-(2,4-difluorophenyl)sulfonylethylthio]-N-(2-thienylmethyl)-nicotinamide | 1134168-91-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-[2-(2,4-difluorophenyl)sulfonylethylthio]-N-(2-thienylmethyl)-nicotinamide
• 英文别名: 2-[2-(2,4-difluorophenyl)sulfonylethylsulfanyl]-N-(thiophen-2-ylmethyl)pyridine-3-carboxamide
• CAS: 1134168-91-4
• 化学式: C₁₉H₁₆F₂N₂O₃S₃
• 分子量: 454.542
• InChiKey: KQKICZOAXYECNX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  138
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• SUBSTITUTED NICOTINAMIDE COMPOUNDS AND USES THEREOF
  申请人：Merla Beatrix

  公开号：US20090076086A1

  公开（公告）日：2009-03-19

  Substituted nicotinamide compounds corresponding to formula I a process for their preparation, pharmaceutical compositions containing these compounds, and the use thereof for the treatment or inhibition conditions such as pain, epilepsy, migraine, anxiety states, or urinary incontinence.

  替代烟酰胺化合物对应于公式I的制备方法，含有这些化合物的药物组合物，以及将其用于治疗或抑制疼痛、癫痫、偏头痛、焦虑状态或尿失禁等疾病的用途。
• SUBSTITUIERTE NICOTINAMID-VERBINDUNGEN UND DEREN VERWENDUNG IN ARZNEIMITTELN
  申请人：Grünenthal GmbH

  公开号：EP2188258A1

  公开（公告）日：2010-05-26
• 1,3 AND 1,3,5 SUBSTITUTED IMIDAZOLES AS ANTIHYPERTENSIVA
  申请人：Eldrug S.A.

  公开号：EP2188279A2

  公开（公告）日：2010-05-26
• US8084470B2
  申请人：——

  公开号：US8084470B2

  公开（公告）日：2011-12-27
• [EN] COMPOUNDS<br/>[FR] COMPOSÉS
  申请人：ELDRUG S A

  公开号：WO2009016514A2

  公开（公告）日：2009-02-05

  The present invention provides novel 1,5 and 1,3, 5 -substituted imidazole compounds of formulas (I), (IIa), (IIIb) in hydrophilic or lipophilic form, which are useful as angiotensin II AT1 receptor antagonists with sympathetic suppressant properties. In particular, the invention provides pharmaceutical compositions containing the pharmacophoric groups of Losartan and Clonidine as well compounds, processes and intermediates for preparing compounds and their use in methods of treating hypertension and cardiovascular diseases through Renin Angiotensin System (RAS) and Sympathetic System (SS). Alkylated histamine based double action Saltans are lipophilic and can act transdermally.