14-(2-Hydroxyethyl)-8-oxa-14-azapentacyclo[10.6.2.02,7.09,19.016,20]icosa-1(19),2,4,6,9,11,16(20),17-octaene-13,15-dione | 37501-66-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 14-(2-Hydroxyethyl)-8-oxa-14-azapentacyclo[10.6.2.02,7.09,19.016,20]icosa-1(19),2,4,6,9,11,16(20),17-octaene-13,15-dione
• CAS: 37501-66-9
• 化学式: C₂₀H₁₃NO₄
• 分子量: 331.328
• InChiKey: ZYHAWUILYWTKQZ-UHFFFAOYSA-N

物化性质

• 沸点：
  603.5±48.0 °C(Predicted)
• 密度：
  1.494±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  14-(2-Hydroxyethyl)-8-oxa-14-azapentacyclo[10.6.2.02,7.09,19.016,20]icosa-1(19),2,4,6,9,11,16(20),17-octaene-13,15-dione 、 2-(2',3',4',6'-tetra-O-acetyl-α-D-galactopyranosyloxy)-1,3,2-dioxaphosphinane 2-oxide 在 三氟甲磺酸三甲基硅酯 作用下， 以69%的产率得到[(2R,3S,4S,5R,6R)-3,4,5-triacetyloxy-6-[2-(13,15-dioxo-8-oxa-14-azapentacyclo[10.6.2.02,7.09,19.016,20]icosa-1(19),2,4,6,9,11,16(20),17-octaen-14-yl)ethoxy]oxan-2-yl]methyl acetate
  参考文献：
  名称：

  Synthesis of a novel oxoxanthenoisoquinoline via a palladium-catalysed cross-coupling reaction; as a fluorophore

  摘要：

  Suzuki cross-coupling of a bromoaromatic anhydride with 2-methoxyboronic acid afforded a novel oxoxanthenoisoquinoline. Subsequent coupling with 2,3,4,6-tetra-0-acetyl-D-galactose- 1,3-diyl phosphate gave a fluorophore. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00288-4
• 作为产物：
  描述：

  5-溴苊 在 palladium on activated charcoal palladium diacetate 、 sodium dichromate 、 三溴化硼 、 sodium carbonate 作用下， 以 二苯醚 、 二氯甲烷 、 水 、 溶剂黄146 、 甲苯 为溶剂， 反应 45.0h， 生成 14-(2-Hydroxyethyl)-8-oxa-14-azapentacyclo[10.6.2.02,7.09,19.016,20]icosa-1(19),2,4,6,9,11,16(20),17-octaene-13,15-dione
  参考文献：
  名称：

  Synthesis of a novel oxoxanthenoisoquinoline via a palladium-catalysed cross-coupling reaction; as a fluorophore

  摘要：

  Suzuki cross-coupling of a bromoaromatic anhydride with 2-methoxyboronic acid afforded a novel oxoxanthenoisoquinoline. Subsequent coupling with 2,3,4,6-tetra-0-acetyl-D-galactose- 1,3-diyl phosphate gave a fluorophore. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00288-4

文献信息

• Counterstains for a biological sample
  申请人：Key Marc

  公开号：US10718694B2

  公开（公告）日：2020-07-21

  The present disclosure relates to counterstains for staining a biological sample on a single slide in preparation for microscopic examination. The counterstains are used to analyze the sample on the single slide using both brightfield and fluorescent illumination. The counterstains can identify both morphological details and molecular structures within the cells contained in the sample. The counterstains can be used in conjunction with other molecular stains.

  本公开涉及用于在单张载玻片上对生物样本进行染色以备显微镜检查的反染色剂。使用明视野和荧光照明对单张载玻片上的样本进行分析。反印迹可以识别样本中细胞的形态细节和分子结构。反印迹可与其他分子染色法结合使用。
• COUNTERSTAINS FOR A BIOLOGICAL SAMPLE
  申请人：KEY MARC

  公开号：US20170299482A1

  公开（公告）日：2017-10-19

  The present disclosure relates to counterstains for staining a biological sample on a single slide in preparation for microscopic examination. The counterstains are used to analyze the sample on the single slide using both brightfield and fluorescent illumination. The counterstains can identify both morphological details and molecular structures within the cells contained in the sample. The counterstains can be used in conjunction with other molecular stains.