N,N'-(ethane-1,2-diyl)-bis(N-ethyl-3,5-difluoro-4-hydroxybenzenesulfonamide) | 1217502-75-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-(ethane-1,2-diyl)-bis(N-ethyl-3,5-difluoro-4-hydroxybenzenesulfonamide)
• 英文别名: N,N''-(ethane-1,2-diyl)bis(N-ethyl-3,5-difluoro-4-hydroxybenzenesulfonamide)；N-[2-[(3,5-difluoro-4-hydroxyphenyl)sulfonyl-ethylamino]ethyl]-N-ethyl-3,5-difluoro-4-hydroxybenzenesulfonamide
• CAS: 1217502-75-4
• 化学式: C₁₈H₂₀F₄N₂O₆S₂
• 分子量: 500.492
• InChiKey: DMOZXQUMPYUSHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  132
• 氢给体数：
  2
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  N,N'-(ethane-1,2-diyl)-bis(N-ethyl-3,5-difluoro-4-methoxybenzenesulfonamide) 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 以67%的产率得到N,N'-(ethane-1,2-diyl)-bis(N-ethyl-3,5-difluoro-4-hydroxybenzenesulfonamide)
  参考文献：
  名称：

  Novel bis-arylsulfonamides and aryl sulfonimides as inactivators of plasminogen activator inhibitor-1 (PAI-1)

  摘要：

  Inactivators of plasminogen activator inhibitor-1 (PAI-1) have been identified as possible treatments for a range of conditions, including atherosclerosis, venous thrombosis, and obesity. We describe the synthesis and inhibitory activity of a novel series of compounds based on bis-arylsulfonamide and aryl sulfonimide motifs that show potent and specific activity towards PAI-1. Inhibitors containing short linking units between the sulfonyl moieties and a 3,4-dihydroxy aryl substitution pattern showed the most potent inhibitory activity, and retained high specificity for PAI-1 over the structurally-related serpin anti-thrombin III (ATIII). (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.12.051

文献信息

• Plasminogen Activator Inhibitor-1 Inhibitors and Methods of Use Thereof to Modulate Lipid Metabolism
  申请人：Lawrence Daniel A.

  公开号：US20100137194A1

  公开（公告）日：2010-06-03

  The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.

  本发明涉及纤溶酶原激活剂-1（PAI-1）抑制剂化合物及其在治疗任何与升高的PAI-1相关的疾病或病状中的应用。本发明包括但不限于使用这些化合物来调节脂质代谢并治疗与升高的PAI-1、胆固醇或脂质水平相关的病症。
• PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITORS AND METHODS OF USE THEREOF TO MODULATE LIPID METABOLISM
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US20160009748A1

  公开（公告）日：2016-01-14

  The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.

  本发明涉及纤溶酶原激活物-1（PAI-1）抑制剂化合物及其在治疗与升高的PAI-1相关的任何疾病或病况中的用途。本发明包括但不限于使用这样的化合物来调节脂质代谢并治疗与升高的PAI-1、胆固醇或脂质水平相关的病症。
• US9120744B2
  申请人：——

  公开号：US9120744B2

  公开（公告）日：2015-09-01
• US9527878B2
  申请人：——

  公开号：US9527878B2

  公开（公告）日：2016-12-27
• Novel bis-arylsulfonamides and aryl sulfonimides as inactivators of plasminogen activator inhibitor-1 (PAI-1)
  作者：Nadine C. El-Ayache、Shih-Hon Li、Mark Warnock、Daniel A. Lawrence、Cory D. Emal

  DOI：10.1016/j.bmcl.2009.12.051

  日期：2010.2

  Inactivators of plasminogen activator inhibitor-1 (PAI-1) have been identified as possible treatments for a range of conditions, including atherosclerosis, venous thrombosis, and obesity. We describe the synthesis and inhibitory activity of a novel series of compounds based on bis-arylsulfonamide and aryl sulfonimide motifs that show potent and specific activity towards PAI-1. Inhibitors containing short linking units between the sulfonyl moieties and a 3,4-dihydroxy aryl substitution pattern showed the most potent inhibitory activity, and retained high specificity for PAI-1 over the structurally-related serpin anti-thrombin III (ATIII). (c) 2009 Elsevier Ltd. All rights reserved.