(4R,6S)-6-((E)-2-(2-cyclopropyl-4-(4-fluorophenylthio)-6-methoxyquinolin-3-yl)vinyl)-4-hydroxytetrahydro-2H-pyran-2-one | 1202383-07-0

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: (4R,6S)-6-((E)-2-(2-cyclopropyl-4-(4-fluorophenylthio)-6-methoxyquinolin-3-yl)vinyl)-4-hydroxytetrahydro-2H-pyran-2-one
• 英文别名: (4R,6S)-6-[(E)-2-[2-cyclopropyl-4-(4-fluorophenyl)sulfanyl-6-methoxyquinolin-3-yl]ethenyl]-4-hydroxyoxan-2-one
• CAS: 1202383-07-0
• 化学式: C₂₆H₂₄FNO₄S
• 分子量: 465.545
• InChiKey: ACWKFPLYGSQYHM-LVJUENIKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  94
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (4R,6S)-6-((E)-2-(2-cyclopropyl-4-(4-fluorophenylthio)-6-methoxyquinolin-3-yl)vinyl)-4-hydroxytetrahydro-2H-pyran-2-one 在 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and HMG-CoA reductase inhibition of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones

  摘要：

  A novel series of 2-cyclopropyl-4-thiophenyl quinoline-based mevalonolactones were synthesized from the substituted anilines by several reactions. Among them, (4R,6S)-6-[(E)-2-(2-cyclopropyl-6-fluoro-4-(4-fluoro-thiophenyl)-quinoline-3-yl)-ethenyl]-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one (1d), (4R,6S)-6-[(E)-2-(2-cyclopropyl-6-fluoro-4-(3-methoxy-thiophenyl)-quinoline-3-yl)-ethenyl]-3,4,5,6-tetra-hydro-4-hydroxy-2H-pyran-2-one (1f) and (4R,6S)-6-[(E)-2-(2-cyclopropyl-6-fluoro-4,7-di(3-methoxy-thiophenyl)-quinoline-3-yl)-ethenyl]-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one (1q) showed potent HMG-CoA reductase inhibitory activity comparable with pitavastatin. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.10.021
• 作为产物：
  描述：

  tert-butyl 2-((4R,6S)-6-((E)-2-(2-cyclopropyl-4-((4-fluorophenyl)thio)-6-methoxyquinolin-3-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 以57%的产率得到(4R,6S)-6-((E)-2-(2-cyclopropyl-4-(4-fluorophenylthio)-6-methoxyquinolin-3-yl)vinyl)-4-hydroxytetrahydro-2H-pyran-2-one
  参考文献：
  名称：

  Synthesis and HMG-CoA reductase inhibition of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones

  摘要：

  A novel series of 2-cyclopropyl-4-thiophenyl quinoline-based mevalonolactones were synthesized from the substituted anilines by several reactions. Among them, (4R,6S)-6-[(E)-2-(2-cyclopropyl-6-fluoro-4-(4-fluoro-thiophenyl)-quinoline-3-yl)-ethenyl]-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one (1d), (4R,6S)-6-[(E)-2-(2-cyclopropyl-6-fluoro-4-(3-methoxy-thiophenyl)-quinoline-3-yl)-ethenyl]-3,4,5,6-tetra-hydro-4-hydroxy-2H-pyran-2-one (1f) and (4R,6S)-6-[(E)-2-(2-cyclopropyl-6-fluoro-4,7-di(3-methoxy-thiophenyl)-quinoline-3-yl)-ethenyl]-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one (1q) showed potent HMG-CoA reductase inhibitory activity comparable with pitavastatin. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.10.021

文献信息

• Synthesis and HMG-CoA reductase inhibition of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones
  作者：Shikui Zhao、Weicheng Zhou、Jun liu

  DOI：10.1016/j.bmc.2009.10.021

  日期：2009.12

  A novel series of 2-cyclopropyl-4-thiophenyl quinoline-based mevalonolactones were synthesized from the substituted anilines by several reactions. Among them, (4R,6S)-6-[(E)-2-(2-cyclopropyl-6-fluoro-4-(4-fluoro-thiophenyl)-quinoline-3-yl)-ethenyl]-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one (1d), (4R,6S)-6-[(E)-2-(2-cyclopropyl-6-fluoro-4-(3-methoxy-thiophenyl)-quinoline-3-yl)-ethenyl]-3,4,5,6-tetra-hydro-4-hydroxy-2H-pyran-2-one (1f) and (4R,6S)-6-[(E)-2-(2-cyclopropyl-6-fluoro-4,7-di(3-methoxy-thiophenyl)-quinoline-3-yl)-ethenyl]-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one (1q) showed potent HMG-CoA reductase inhibitory activity comparable with pitavastatin. (c) 2009 Elsevier Ltd. All rights reserved.