N-(1-(pyridin-4-yl)propyl)-5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)pyrimidin-2-amine | 1441873-08-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-(1-(pyridin-4-yl)propyl)-5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)pyrimidin-2-amine
• 英文别名: US9670193, 15 N-(1-(pyridin-4-yl)propyl)-5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)pyrimidin-2-amine；N-(1-pyridin-4-ylpropyl)-5-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]pyrimidin-2-amine
• CAS: 1441873-08-0
• 化学式: C₁₅H₁₃F₃N₆O
• 分子量: 350.303
• InChiKey: BSYYWKPZYHEVAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  89.6
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• [EN] NOVEL TRIFLUOROMETHYL-OXADIAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE<br/>[FR] NOUVEAUX DÉRIVÉS TRIFLUOROMÉTHYL-OXADIAZOLES ET LEUR UTILISATION DANS LE TRAITEMENT DE MALADIES
  申请人：NOVARTIS AG

  公开号：WO2013080120A1

  公开（公告）日：2013-06-06

  The invention relates to novel trifluoromethyl-oxadiazole derivatives of formula (I), and pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, pharmaceutical combinations thereof, and their use as medicaments, particularly for the treatment of neurodegeneration, muscle atrophy or diabetes/metabolic syndrome via inhibition of HDAC4.

  该发明涉及一种新型三氟甲基-噁二唑衍生物的公式(I)，以及其药学上可接受的盐，其中所有变量均如规范中定义，其药物组合物，药物组合物及其作为药物的用途，特别用于通过抑制HDAC4治疗神经退行性疾病、肌肉萎缩或糖尿病/代谢综合征。
• NOVEL TRIFLUOROMETHYL-OXADIAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE
  申请人：Hebach Christina

  公开号：US20140329825A1

  公开（公告）日：2014-11-06

  The invention relates to novel trifluoromethyl-oxadiazole derivatives of formula (I), and pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, pharmaceutical combinations thereof, and their use as medicaments, particularly for the treatment of neurodegeneration, muscle atrophy or diabetes/metabolic syndrome via inhibition of HDAC4.

  本发明涉及一种新型三氟甲基-噁二唑衍生物，其化学式为（I），以及其药物可接受的盐。其中所有变量如规范所定义，包括其制药组合物、制药组合物的药物组成物以及它们作为药物的用途，特别是通过抑制HDAC4治疗神经退行性、肌肉萎缩或糖尿病/代谢综合征。
• [EN] 1,2,4-OXADIAZOL-3-YL PYRIMIDINES AS FUNGICIDES<br/>[FR] 1,2,4-OXADIAZOL-3-YL PYRIMIDINES EN TANT QUE FONGICIDES
  申请人：BAYER AG

  公开号：WO2022129188A1

  公开（公告）日：2022-06-23

  The present invention relates to 1,2,4-oxadiazol-3-ylpyrimidine compounds as well as the uses thereof for controlling harmful microorganisms, in particular phytopathogenic fungi, in crop protection (formula (I)).

  本发明涉及1,2,4-噁二唑-3-基嘧啶化合物及其在作物保护中控制有害微生物，特别是植物病原真菌的用途（式（I））。
• US9670193B2
  申请人：——

  公开号：US9670193B2

  公开（公告）日：2017-06-06