Methyl 4-[5-[2-hydroxy-2-(4-methoxycarbonylphenyl)ethyl]-3-pent-4-enylfuran-2-yl]benzoate | 1204300-09-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 4-[5-[2-hydroxy-2-(4-methoxycarbonylphenyl)ethyl]-3-pent-4-enylfuran-2-yl]benzoate
• CAS: 1204300-09-3
• 化学式: C₂₇H₂₈O₆
• 分子量: 448.516
• InChiKey: IMFJKWKIFHXRHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  33
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  86
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  methyl 4-[1-hydroxy-5-[hydroxy-(4-methoxycarbonylphenyl)methyl]deca-5,9-dien-3-ynyl]benzoate 在 chloro(triphenylphosphine)silver(I) 、 silver trifluoromethanesulfonate 作用下， 以 二氯甲烷 为溶剂， 以90%的产率得到Methyl 4-[5-[2-hydroxy-2-(4-methoxycarbonylphenyl)ethyl]-3-pent-4-enylfuran-2-yl]benzoate
  参考文献：
  名称：

  Gold-catalyzed cyclization of enyne-1,6-diols to substituted furans

  摘要：

  Treatment of enyne-1,6-diols with 5 mol % Ph3PAuCl in the presence of 5 mol % AgOTf as a cocatalyst selectively produced trisubstituted furans in good to excellent yields in dichloromethane at room temperature for 5-10 min through cyclization followed by isomerization. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.02.026

文献信息

• Gold-catalyzed cyclization of enyne-1,6-diols to substituted furans
  作者：Sundae Kim、Dongjin Kang、Seunghoon Shin、Phil Ho Lee

  DOI：10.1016/j.tetlet.2010.02.026

  日期：2010.4

  Treatment of enyne-1,6-diols with 5 mol % Ph3PAuCl in the presence of 5 mol % AgOTf as a cocatalyst selectively produced trisubstituted furans in good to excellent yields in dichloromethane at room temperature for 5-10 min through cyclization followed by isomerization. (C) 2010 Elsevier Ltd. All rights reserved.