N-(4-phenyl-6-(4-methoxyphenyl)-pyrimidin-2-yl)-2-morpholinoacetamide | 1031977-74-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-(4-phenyl-6-(4-methoxyphenyl)-pyrimidin-2-yl)-2-morpholinoacetamide
• 英文别名: N-(4-Phenyl-6-(4-methoxyphenyl)-pyrimidin-2-yl)2-morpholinoacetamide；N-[4-(4-methoxyphenyl)-6-phenylpyrimidin-2-yl]-2-morpholin-4-ylacetamide
• CAS: 1031977-74-8
• 化学式: C₂₃H₂₄N₄O₃
• mdl: MFCD27589051
• 分子量: 404.469
• InChiKey: LGAGZWZHEYEMTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  76.6
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  吗啉 、 C₁₉H₁₆ClN₃O₂ 在 potassium carbonate 作用下， 以 甲苯 为溶剂， 以88%的产率得到N-(4-phenyl-6-(4-methoxyphenyl)-pyrimidin-2-yl)-2-morpholinoacetamide
  参考文献：
  名称：

  Design, Synthesis and Spectral Characterization of Novel 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides

  摘要：

  在无水碳酸钾存在下，通过将2-氯-N-(4,6-二芳基嘧啶-2-基)乙酰胺25-33与莫尔福林缩合反应，合成了一系列新的2-莫尔福林-N-(4,6-二芳基嘧啶-2-基)乙酰胺34-42。合成的化合物通过熔点、元素分析、质谱（MS）、傅里叶变换红外光谱（FT-IR）以及一维核磁共振（$^1H$ & $^{13}C$）光谱数据进行了表征。

  DOI：

  10.5012/jkcs.2010.54.01.049

文献信息

• Design, Synthesis and Spectral Characterization of Novel 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides
  作者：Vijayakumar Kanagarajan、Jayaraman Thanusu、Mannathusamy Gopalakrishnan

  DOI：10.5012/jkcs.2010.54.01.049

  日期：2010.2.20

  무수탄산칼륨 존재 하에서 2-chloro-N-(4,6-diarylpyrimidin-2-yl)acetamides 25-33를 모르포린과 축합 반응시켜서 2-morpholino-N-(4,6-diarylpyrimidin-2yl)acetamides 34-42 화합물들을 합성하였다. 합성된 화합물들의 녹는점, 원소분석, MS, FT-IR, $^1H$- & $^13}C$-NMR로 화학적인 구조를 규명되었다. A new series of novel 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides 34-42 is synthesized by the condensation of 2-chloro-N-(4,6-diarylpyrimidin-2-yl)acetamides 25-33 with morpholine in the presence of anhydrous potassium carbonate. The synthesized compounds have been characterized by melting point, elemental analysis, MS, FT-IR, one-dimensional NMR ($^1H$ & $^13}C$) spectroscopic data.

  在无水碳酸钾存在下，通过将2-氯-N-(4,6-二芳基嘧啶-2-基)乙酰胺25-33与莫尔福林缩合反应，合成了一系列新的2-莫尔福林-N-(4,6-二芳基嘧啶-2-基)乙酰胺34-42。合成的化合物通过熔点、元素分析、质谱（MS）、傅里叶变换红外光谱（FT-IR）以及一维核磁共振（$^1H$ & $^13}C$）光谱数据进行了表征。
• Synthesis and in vitro microbiological evaluation of an array of biolabile 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides
  作者：V. Kanagarajan、J. Thanusu、M. Gopalakrishnan

  DOI：10.1016/j.ejmech.2009.12.068

  日期：2010.4

  Biolabile 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides 34-42 have been synthesized and evaluated for their in vitro antibacterial and antifungal activities. The minimum inhibitory concentration tested for the same compounds against the same set of bacterial and fungal strains shows that the compounds 36 and 38 against beta-Heamolytic streptococcus and Klebsiella pneumonia, 40 against Escherichia coli and Pseudomonas, have excellent antibacterial activity. Compounds 36, 38 and 42 show inhibition against Aspergillus flavus, compound 41 against Microsporum gypsuem, 42 against Mucor, and compounds 39 and 40 against Rhizopus. (c) 2010 Elsevier Masson SAS. All rights reserved.