2,6-dihydro-1H-pyrazolo[3,4-b]pyridine | 18417-64-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2,6-dihydro-1H-pyrazolo[3,4-b]pyridine
• 英文别名: 6,7-dihydro-1H-pyrazolo[3,4-b]pyridine
• CAS: 18417-64-6
• 化学式: C₆H₇N₃
• 分子量: 121.14
• InChiKey: OVOHTXQYQLNXEQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  36.4
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• ISOQUINOLINES AS INHIBITORS OF HPK1
  申请人：Genentech, Inc.

  公开号：US20210163417A1

  公开（公告）日：2021-06-03

  Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.