1-(N-methylbenzimidazolyl)-3-benzimidazolyl-2-oxapropane | 184482-95-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-(N-methylbenzimidazolyl)-3-benzimidazolyl-2-oxapropane
• 英文别名: 2-(1H-benzimidazol-2-ylmethoxymethyl)-1-methylbenzimidazole
• CAS: 184482-95-9
• 化学式: C₁₇H₁₆N₄O
• 分子量: 292.34
• InChiKey: XGOOARLWLRXXKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  55.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(N-methylbenzimidazolyl)-3-benzimidazolyl-2-oxapropane 、 copper(II) perchlorate 以 甲醇 为溶剂， 生成 Cu(1-(N-methylbenzimidazolyl)-3-benzimidazolyl-2-oxapropane)(ClO4)2 * H2O
  参考文献：
  名称：

  A Route to Bis(benzimidazole) Ligands with Built-In Asymmetry:  Potential Models of Protein Binding Sites Having Histidines of Different Basicity

  摘要：

  A synthetic strategy has been developed for bis(benzimidazole) ligands in which the two halves are different (4-11), and consequently of different basicity, which could be important for biomimicry and metal ion transport. Their coordination chemistry toward copper(II) has been studied in the solid state via X-ray crystallography. The ligands were complexed with copper(II) bromide and perchlorate salts to yield complexes of a 1:1 stoichiometry. Crystal structures have been determined and compared for [Cu(4)(NCCH3)(OH2)](ClO4)(2) (complex A, [C20H23CuN5O2](ClO4)(2), monoclinic, space group P2(1)/c, a = 10.2168(7) Angstrom, b = 30.740(2) Angstrom, c = 8.3403(6) Angstrom, beta = 105.960(2)degrees, V = 2518.4(3) Angstrom(3), Z = 4), [Cu(6)Br-2]. DMF (complex B, [C17H16Br2CuN4O]. C3H7NO, monoclinic, space group P2(1)/c, a = 8.3348(11) Angstrom, b = 18.165(2) Angstrom, c = 14.140(2) Angstrom, beta = 91.646(3)degrees, V = 2140.0(5) Angstrom(3), Z 4), [Cu(8)Br-2]. DMF . H2O (complex C, [C16H13Br2CuN5O3]. C3H7NO . H2O, monoclinic, space group P2(1)/c, a = 8.7241(10) Angstrom, b = 18.172(2) Angstrom, c = 14.506(2) Angstrom, beta = 97.376(2)degrees, V = 2280.7(4) Angstrom(3), Z = 4), [Cu(3)Br-2]. MeOH (complex D, [C16H14Br2CuN4O]. CH4O, orthorhombic, space group Pbca, a = 14.325(2) Angstrom, b = 13.919(2) Angstrom, c = 18.837(2) Angstrom, V = 3756.0(9) Angstrom(3), Z = 8), [Cu(4)Br-2]. MeOH (complex E, [C18H18Br2CuN4O]. CH4O, triclinic, space group , a = 7.3120(11) Angstrom, b = 9.9460(15) Angstrom, c = 15.189(2) Angstrom, alpha = 87.476(4)degrees, beta = 89.093(4)degrees, gamma = 68.673(3)degrees, V = 1028.0(3) Angstrom(3), Z = 2), and Cu(10)Br-2 (complex F, C16H13Br2CuN3OS, monoclinic, space group P2(1)/c, a = 7.3130(9) Angstrom, b = 15.861(2) Angstrom, c = 14.846(2) Angstrom, beta = 98.318(2)degrees, V = 1704.0(4) Angstrom(3), Z = 4). The Cu(II) complexes were found to be five;coordinate, lying between perfect square-based-pyramidal (SEP) and trigonal-bipyramidal (TBP) extremes; in each case the ligands act as tridentate donors coordinating through the pyridine-like nitrogens of the benzimidazole moieties and the ether donor atom of the linking bridge. Use of the structural index parameter (tau) for five-coordinate metal complexes indicated that all the copper(II) complexes exhibit a greater tendency toward square-based-pyramidal geometry (i.e. tau < 0.5). Comparison of the symmetrical bis(benzimidazole) complex with the other, asymmetric, complexes revealed no significant change in the geometrical parameters around the copper(II) ion consequent on introduction of asymmetry and a change of pKa within the bis(benzimidazole) fragment. The degree of hydrogen bonding, solvent of crystallization, and the nature of the anion have a greater impact on the geometrical parameters and coordination environment of the copper(II) ion. The import for biological metal coordination is considered.

  DOI：

  10.1021/ic960777m