3-chloro-3',4'-dihydroxydiphenylmethanone | 463355-58-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-chloro-3',4'-dihydroxydiphenylmethanone
• 英文别名: (3-Chlorophenyl)-(3,4-dihydroxyphenyl)methanone
• CAS: 463355-58-0
• 化学式: C₁₃H₉ClO₃
• 分子量: 248.666
• InChiKey: OKVYGRRZCARIFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-氯-3′,4′-二甲氧基二苯酮 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 生成 3-chloro-3',4'-dihydroxydiphenylmethanone
  参考文献：
  名称：

  Synthesis and biological activity of halophenols as potent antioxidant and cytoprotective agents

  摘要：

  A series of new bromophenols and chlorophenols were prepared by a practical route. The in vitro antioxidative activity of the halophenols was evaluated by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging assay, and their cytoprotective activity was also tested on hydrogen peroxide (H2O2)-induced injury in human umbilical vein endothelial cells (HUVEC). All halophenols tested displayed moderate to good DPPH radical-scavenging activity, and two bromophenols, 2,3'-dibromo-4,5,6'-trihydroxydiphenyl-methanone (16c) and 2,3-dibromo-4,5-dihydroxydiphenylmethanone (17c) exhibited high protective activity against H2O2-induced injury in HUVEC with EC50 values of 0.4 and 0.8 mu M, respectively. The preliminary structure-activity relationships of these compounds were also investigated in order to determine the essential structures required for their bioactivities. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.05.068

文献信息

• Thermographic recording material providing prints with good image density and tone having improved archivability
  申请人：AGFA-GEVAERT

  公开号：EP1245404A1

  公开（公告）日：2002-10-02

  A monosheet black and white substantially light-insensitive thermographic recording material comprising a thermosensitive element and a support, the thermosensitive element containing a substantially light-insensitive organic silver salt, a 3,4-dihydroxybenzene compound in thermal working relationship therewith and a binder, characterized in that the 3,4-dihydroxybenzene compound is an aryloxo-3,4-dihydroxybenzene compound in which the aryl-group is substituted with at least one substituent having a σm-value greater than 0; or a heteroaryloxo-3,4-dihydroxybenzene compound in which the heteroaryl group has a unified aromaticity index IA greater than 53 and is optionally substituted with at least one group selected from the group consisting of aryl, hydroxy, carboxy, sulfo, sulfoalkyl, sulfoaryl, sulfonylalkyl, sulfonylaryl, annulated aryl, annulated heteroaryl, carboxyalkyl, carboxyaryl, oxoalkyl, oxoaryl, halogen, nitro, cyano and mercapto-alkyl groups; and a thermographic recording process therefor.

  一种单片黑白基本感光热敏记录材料，包括热敏元件和支持物，热敏元件含有基本感光的有机银盐、与之有热工作关系的3，4-二羟基苯化合物和粘合剂，其特征在于3，4-二羟基苯化合物是芳氧基-3，4-二羟基苯化合物，其中芳基被至少一个取代基取代，该取代基的σm-值大于0；或杂芳氧基-3,4-二羟基苯化合物，其中杂芳基的统一芳香指数 IA 大于 53，并可选择被至少一个选自芳基的基团取代、羟基、羧基、亚砜基、亚砜烷基、亚砜芳基、磺酰基烷基、磺酰基芳基、环芳基、环杂芳基、羧基烷基、羧基芳基、氧代烷基、氧代芳基、卤素、硝基、氰基和巯基烷基所组成的组；及其热成像记录工艺。