1-[5-[2-(ethylcarbamoylamino)-7-pyrazin-2-yl-1,3-benzothiazol-5-yl]pyrimidin-2-yl]-4-propyl-piperidine-4-carboxylic acid | 1372546-24-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-[5-[2-(ethylcarbamoylamino)-7-pyrazin-2-yl-1,3-benzothiazol-5-yl]pyrimidin-2-yl]-4-propyl-piperidine-4-carboxylic acid
• 英文别名: 1-[5-[2-(Ethylcarbamoylamino)-7-pyrazin-2-yl-1,3-benzothiazol-5-yl]pyrimidin-2-yl]-4-propylpiperidine-4-carboxylic acid
• CAS: 1372546-24-1
• 化学式: C₂₇H₃₀N₈O₃S
• 分子量: 546.653
• InChiKey: KEVFMPICOSXSNM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  39
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  174
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• ANTIBACTERIAL COMPOUNDS
  申请人：PALMER James T.

  公开号：US20120088750A1

  公开（公告）日：2012-04-12

  The present invention provides a compound of the following formula and salts thereof: Also provided is the use of these compounds as antibacterials, compositions comprising them and processes for their manufacture.

  本发明提供了一种具有以下公式和其盐类的化合物： 还提供了这些化合物作为抗生素的使用，包括它们的组合物以及它们的制造工艺。
• Antibacterial Compounds
  申请人：BIOTA EUROPE LTD

  公开号：US20170007615A1

  公开（公告）日：2017-01-12

  The present disclosure relates to a novel combination of compounds, their use as antibacterials, compositions comprising them and methods for treating or preventing bacterial infections, more particularly, bacterial infections caused by Gram-negative pathogens and/or drug resistant Gram-negative bacteria.
• US9181234B2
  申请人：——

  公开号：US9181234B2

  公开（公告）日：2015-11-10
• [EN] BACTERIA TOPOISOMERASE II INHIBITING 2-ETHYLCARBAMOYLAMINO-1, 3-BENZOTHIAZOL-5-YLS<br/>[FR] 2-ÉTHYLCARBAMOYLAMINO-1,3-BENZOTHIAZOL-5-YLES INHIBITEURS DE TOPOISOMÉRASE II BACTÉRIENNE
  申请人：BIOTA EUROPE LTD

  公开号：WO2012045124A1

  公开（公告）日：2012-04-12

  The present invention provides a compound of the following formula and salts thereof: Also provided is the use of these compounds as antibacterials, compositions comprising them and processes for their manufacture.