4-Methoxy-2-(methylsulfanyl)-6-(trifluoromethyl)-5-pyrimidinecarboxylic acid | 1186404-89-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-Methoxy-2-(methylsulfanyl)-6-(trifluoromethyl)-5-pyrimidinecarboxylic acid
• 英文别名: 4-methoxy-2-methylsulfanyl-6-(trifluoromethyl)pyrimidine-5-carboxylic acid
• CAS: 1186404-89-6
• 化学式: C₈H₇F₃N₂O₃S
• 分子量: 268.22
• InChiKey: VCTUUTHJXNTUKY-UHFFFAOYSA-N

物化性质

• 熔点：
  158-159°

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  97.6
• 氢给体数：
  1
• 氢受体数：
  9

安全信息

• 危险等级：
  IRRITANT

文献信息

• TRPV3 MODULATORS
  申请人：AbbVie Inc.

  公开号：US20180243298A1

  公开（公告）日：2018-08-30

  A compound of Formula (I) having efficacy for the treatment or prevention of conditions and disorders related to TRPV3 activity, e.g. pain, atopic dermatitis, eczema, itch or psoriasis, is disclosed. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.
• [EN] N-(1,3-THIAZOL-2-YL)PYRIMIDINE-5-CARBOXAMIDES AS TRPV3 MODULATORS<br/>[FR] N-(1,3-THIAZOL-2-YL) PYRIMIDINE-5-CARBOXAMIDES EN TANT QUE MODULATEURS DE TRPV3
  申请人：ABBVIE INC

  公开号：WO2016160938A1

  公开（公告）日：2016-10-06

  A compound of Formula (I) having efficacy for the treatment or prevention of conditions and disorders related to TRPV3 activity, e.g. pain, atopic dermatitis, eczema, itch or psoriasis, is disclosed. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.