5-[L-alaninyl]-amino-5,7-dihydro-6H,7H-dibenz[b,d]azepin-6-one Hydrochloride | 1055089-28-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 5-[L-alaninyl]-amino-5,7-dihydro-6H,7H-dibenz[b,d]azepin-6-one Hydrochloride
• 英文别名: (2S)-2-amino-N-(6-oxo-7H-benzo[d][1]benzazepin-5-yl)propanamide;hydrochloride
• CAS: 1055089-28-5
• 化学式: C₁₇H₁₇N₃O₂*ClH
• 分子量: 331.802
• InChiKey: YZAGLQRMIMUROF-MERQFXBCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.04
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  75.4
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
  申请人：——

  公开号：US20030149022A1

  公开（公告）日：2003-08-07

  Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

  本发明涉及一种抑制β-淀粉样肽释放和/或其合成的化合物，因此在治疗阿尔茨海默病方面具有实用性。本发明还涉及包含抑制β-淀粉样肽释放和/或其合成的化合物的药物组合物，以及使用这种药物组合物预防和治疗阿尔茨海默病的方法。
• Cyclic amino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
  申请人：——

  公开号：US20030162768A1

  公开（公告）日：2003-08-28

  Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

  本发明涉及一种抑制β-淀粉样肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的用途。还公开了包含抑制β-淀粉样肽释放和/或其合成的化合物的药物组合物，以及使用这些药物组合物预防和治疗阿尔茨海默病的方法。
• CYCLIC AMINO ACID COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING $g(b)-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS
  申请人：Elan Pharmaceuticals, Inc.

  公开号：EP1093372A1

  公开（公告）日：2001-04-25
• EP1093372A4
  申请人：——

  公开号：EP1093372A4

  公开（公告）日：2004-09-29
• US6528505B1
  申请人：——

  公开号：US6528505B1

  公开（公告）日：2003-03-04