N-butanoyl-1-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide | 705930-48-9

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 三唑核糖核苷和核糖核苷酸
• 英文名称: N-butanoyl-1-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide
• CAS: 705930-48-9
• 化学式: C₁₂H₁₈N₄O₆
• 分子量: 314.298
• InChiKey: ASRRAPGOYOTWPF-GTBBIVDNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  147
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• ANTIVIRAL NUCLEOSIDE DERIVATIVES
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1572710A2

  公开（公告）日：2005-09-14
• [EN] ANTIVIRAL NUCLEOSIDE DERIVATIVES<br/>[FR] DERIVES DE NUCLEOSIDE ANTIVIRAUX
  申请人：HOFFMANN LA ROCHE

  公开号：WO2004052905A2

  公开（公告）日：2004-06-24

  The present invention relates to nucleoside derivatives for the treatment of Hepatitis C viral infections including compounds of formula (I) and (II), pharmaceutical compositions comprising these compounds and methods for treatment or prophylaxis of Hepatitis C Virus mediated diseases employing said compounds in monotherapy or in combination therapy.