2-(β-D-galactopyranosyloxy)-1,5,8-trihydroxy-9,10-anthraquinone | 1220908-46-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 2-(β-D-galactopyranosyloxy)-1,5,8-trihydroxy-9,10-anthraquinone
• 英文别名: 1,5,8-trihydroxy-2-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyanthracene-9,10-dione
• CAS: 1220908-46-2
• 化学式: C₂₀H₁₈O₁₁
• 分子量: 434.356
• InChiKey: NBRPVPSDEAWJEN-CKXFATBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  31
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  194
• 氢给体数：
  7
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  2-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyloxy)-1,5,8-trihydroxy-9,10-anthraquinone 在 乙醇 、 sodium hydroxide 、 盐酸 作用下， 以 水 为溶剂， 以44%的产率得到2-(β-D-galactopyranosyloxy)-1,5,8-trihydroxy-9,10-anthraquinone
  参考文献：
  名称：

  Synthesis of glycoside derivatives of hydroxyanthraquinone with ability to dissolve and inhibit formation of crystals of calcium oxalate. Potential compounds in kidney stone therapy

  摘要：

  Synthesis of glycosyl derivatives of hydroxyanthraquinones (6-10) potentially useful for kidney stone therapy is presented. These compounds were analyzed as inhibitors of calcium oxalate crystals formation as well as substances with the ability of dissolving crystalline calcium oxalate. In addition, the effect of the compounds obtained on real kidney stones was analyzed by ex vivo tests. The tests on L929 and A545 cell lines have shown that the compounds obtained were not cytotoxic. (C) 2009 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.11.042

文献信息

• Synthesis of glycoside derivatives of hydroxyanthraquinone with ability to dissolve and inhibit formation of crystals of calcium oxalate. Potential compounds in kidney stone therapy
  作者：Anna Frąckowiak、Przemysław Skibiński、Wiesław Gaweł、Ewa Zaczyńska、Anna Czarny、Roman Gancarz

  DOI：10.1016/j.ejmech.2009.11.042

  日期：2010.3

  Synthesis of glycosyl derivatives of hydroxyanthraquinones (6-10) potentially useful for kidney stone therapy is presented. These compounds were analyzed as inhibitors of calcium oxalate crystals formation as well as substances with the ability of dissolving crystalline calcium oxalate. In addition, the effect of the compounds obtained on real kidney stones was analyzed by ex vivo tests. The tests on L929 and A545 cell lines have shown that the compounds obtained were not cytotoxic. (C) 2009 Elsevier Masson SAS. All rights reserved.