N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-5-(6-fluoropyridin-3-yl)pyridine-2-carboxamide | 1187383-80-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-5-(6-fluoropyridin-3-yl)pyridine-2-carboxamide
• CAS: 1187383-80-7
• 化学式: C₂₂H₁₈FN₅O
• 分子量: 387.416
• InChiKey: TYYOEFUWCQRJKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  72.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-amine 、 6'-Fluoro-[3,3'-bipyridine]-6-carboxylic acid 在 N,N-二异丙基乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 生成 N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-5-(6-fluoropyridin-3-yl)pyridine-2-carboxamide
  参考文献：
  名称：

  Discovery of imidazo[1,2-a]pyridines as potent MCH1R antagonists

  摘要：

  A series of imidazo[1,2-a] pyridine derivatives was identified and evaluated for MCH1R binding and antagonistic activity. Introduction of a methyl substituent at the 3-position of imidazo[1,2-a] pyridine provided compounds with a significant improvement in MCH1R affinity. Representative compounds in this series exhibited good potency and brain exposure in rats. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.06.101

文献信息

• Discovery of imidazo[1,2-a]pyridines as potent MCH1R antagonists
  作者：Hiroyuki Kishino、Minoru Moriya、Shunji Sakuraba、Toshihiro Sakamoto、Hidekazu Takahashi、Takao Suzuki、Ryuichi Moriya、Masahiko Ito、Hisashi Iwaasa、Norihiro Takenaga、Akane Ishihara、Akio Kanatani、Nagaaki Sato、Takehiro Fukami

  DOI：10.1016/j.bmcl.2009.06.101

  日期：2009.8

  A series of imidazo[1,2-a] pyridine derivatives was identified and evaluated for MCH1R binding and antagonistic activity. Introduction of a methyl substituent at the 3-position of imidazo[1,2-a] pyridine provided compounds with a significant improvement in MCH1R affinity. Representative compounds in this series exhibited good potency and brain exposure in rats. (C) 2009 Elsevier Ltd. All rights reserved.