3-(Difluoromethyl)pyrazine-2-carboxylic acid | 1443287-46-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3-(Difluoromethyl)pyrazine-2-carboxylic acid
• CAS: 1443287-46-4
• 化学式: C₆H₄F₂N₂O₂
• mdl: MFCD25368595
• 分子量: 174.1
• InChiKey: SGYVAKLKRGJAOT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  63.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Pyrazinecarboxamide Derivatives and Plant Disease Controlling Agents Containing the Same
  申请人：Oda Masatsugu

  公开号：US20090233934A1

  公开（公告）日：2009-09-17

  The present invention provides the compounds represented by the general formula (I): [wherein X is a halogen atom or an (C 1 -C 3 )alkyl group which may be substituted with a halogen atom(s); Y is a hydrogen or halogen atom, or a cyano, a (C 1 -C 3 )alkyl or (C 1 -C 3 )alkoxy group; R is a hydrogen or halogen atom, a cyano group, or a (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl group, (C 2 -C 6 )alkynyl, (C 1 -C 6 )alkoxy, (C 2 -C 6 )alkenyloxy, (C 2 -C 6 )alkynyloxy, (C 1 -C 6 )alkylthio, (C 1 -C 6 )alkylsulfinyl or (C 1 -C 6 )alkylsulfonyl group which may be substituted with a halogen atom(s), a (C 1 -C 6 )alkoxycarbonyl group, a (C 1 -C 6 )alkoxyimino(C 1 -C 3 )alkyl group, a tri(C 1 -C 10 )alkylsilyl group, or a phenyl, phenoxy, pyridyloxy or pyrimidyloxy group which may be substituted with a substituent(s); n is an integer of 1 to 5], which compounds cause reduced loads of deleterious, harmful effects to the earth environment, and exhibit a widened controlling spectrum at lowered chemical application rates, thereby finding useful application as a plant disease controlling agent for agricultural and horticultural uses.

  本发明提供了一种由一般式(I)表示的化合物：[其中，X是卤素原子或(C1-C3)烷基，可以用卤素原子取代；Y是氢原子或卤素原子，或氰基，(C1-C3)烷基或(C1-C3)烷氧基；R是氢原子或卤素原子，氰基，(C1-C6)烷基，(C2-C6)烯基，(C2-C6)炔基，(C1-C6)烷氧基，(C2-C6)烯氧基，(C2-C6)炔氧基，(C1-C6)烷硫基，(C1-C6)烷基亚砜基或(C1-C6)烷基磺酰基，可以用卤素原子取代，(C1-C6)烷氧羰基，(C1-C6)烷氧亚胺基(C1-C3)烷基，三(C1-C10)烷基硅烷基，或苯基，苯氧基，吡啶氧基或嘧啶氧基，可以用取代基取代；n是1到5的整数]，这些化合物可以减少对地球环境的有害影响，并在降低化学施用率的情况下展现出扩大的控制光谱，因此可以作为一种农业和园艺用植物病害防治剂的有用应用。
• PYRAZINECARBOXAMIDE DERIVATIVES AND PLANT DISEASE CONTROLLING AGENTS CONTAINING THE SAME
  申请人：NIHON NOHYAKU CO., LTD.

  公开号：EP1963286A1

  公开（公告）日：2008-09-03
• OXAZINE DERIVATIVES AND THEIR USE AS BACE INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
  申请人：Novartis AG

  公开号：EP2456763A1

  公开（公告）日：2012-05-30
• METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP2665716A1

  公开（公告）日：2013-11-27
• US8168638B2
  申请人：——

  公开号：US8168638B2

  公开（公告）日：2012-05-01