N-(2,2-[1-(3-aminophenyl)ethylidene]hydrazino-2-oxoethyl)benzamide | 1193345-56-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2,2-[1-(3-aminophenyl)ethylidene]hydrazino-2-oxoethyl)benzamide
• 英文别名: N-(2-2-[1-(3-aminophenyl)ethylidene]hydrazino-2-oxoethyl)benzamide
• CAS: 1193345-56-0
• 化学式: C₁₇H₁₈N₄O₂
• 分子量: 310.356
• InChiKey: MVDJQIOEBIAVMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.54
• 重原子数：
  23.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  96.58
• 氢给体数：
  3.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  copper(II) choride dihydrate 、 N-(2,2-[1-(3-aminophenyl)ethylidene]hydrazino-2-oxoethyl)benzamide 以 乙醇 为溶剂， 反应 4.0h， 生成
  参考文献：
  名称：

  Synthesis and Characterization of Divalent Nickel, Copper and Cadmium Complexes of N-(2-2-[1-(3-aminophenyl) ethylidene] hydrazino-2-oxoethyl) Benzamide

  摘要：

  Ni(II) (1)、Cu(II) (2)和Cd(II) (3)与新型席夫碱N-(2-2-[1-(3-氨基苯基)乙亚基]肼基-2-氧代乙基)苯甲酰胺(LH)的复合物已经制备完成，并通过元素分析、TG-DTA、磁学、电子学、摩尔电导率测量、IR、SEM、NMR、ESR和质谱研究进行了表征。观察发现，所有具有1:1金属-配体化学计量的复合物都是四配位的。结果表明，LH通过肼基羰基氧、偶氮亚甲基氮和胺氮作为三齿配体与Cu和Cd离子结合，而与Ni离子结合时，则通过肼基羰基氧和偶氮亚甲基氮作为二齿配体。配体在2中表现出酮-烯醇互变异构，在其中充当单负配体。复合物1和3在DMF溶液中表现为1:1电解质，而复合物2则表现为非电解质。复合物2具有抗磁性且ESR不活跃，这表明铜离子以铜的形式存在。SEM图像用于观察化合物的外部形态。

  DOI：

  10.13005/ojc/300468
• 作为产物：
  描述：

  间氨基苯乙酮 、 N-(2-肼基-2-氧代乙基)苯甲酰胺 以 乙醇 为溶剂， 反应 4.0h， 以60%的产率得到N-(2,2-[1-(3-aminophenyl)ethylidene]hydrazino-2-oxoethyl)benzamide
  参考文献：
  名称：

  Potentiometric Studies on the Complexation Reactions of N-(2,2-[1-(3-Aminophenyl)ethylidene]hydrazino-2-oxoethyl)benzamide with Ni²⁺, Cu²⁺, and Cd²⁺ Ions in Aqueous Dioxane and Micellar Media

  摘要：

  N-(2,2-[1-(3-Aminophenyl)ethylidene] hydrazino-2-oxoethyl)benzamide, aehb, was prepared by condensation of N-benzoyl glycine hydrazide with 3-aminoacetophenone and characterized on the basis of elemental and spectral data. Potentiometric Studies of the Ni(II), Cu(II), and Cd(II) complexes of aehb were carried out at a constant ionic strength (I, mol.dm(-3) = 0.10 M KNO3) at different temperatures, T = (290, 300, and 310) K, in aqueous dioxane (40 %) and in nonionic and anionic micellar media. The ligand accepted one proton in the pH range of 5.0 to 11.0 and reacted with the Ni2+, Cu2+, and Cd2+ ions in all media to form only I: I metal-ligand complexes. The protonation constant of aehb and the stability constants of the complexes had been evaluated from the pH metric titration curves employing Irving and Rossotti's pH metric titration technique. The stability constant of the complexes was in the following order: Cu(II) > Ni(II) > Cd(II). Thermodynamic parameters associated with the protonation and complexation reactions of aehb were also calculated. The values of Delta G and Delta H were negative for all of the systems in all of the media, which Suggested that all of the reactions were exothermic and enthalpy-driven. The presence of surfactants in the media resulted in a decrease of the protonation constant of the ligand and stability constants of the complexes due to the compartmentalizing action of the micelles on the reacting species, and the values in different media followed this trend: aqueous > Triton X-100 (Tx-100) > Labs.

  DOI：

  10.1021/je900583g