1-(1-(1H-benzimidazol-2-yl)ethylideneamino)-4-(2-hydroxyphenyl)-6-(3-nitrobenzylidene-amino)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile | 1338245-71-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-(1-(1H-benzimidazol-2-yl)ethylideneamino)-4-(2-hydroxyphenyl)-6-(3-nitrobenzylidene-amino)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile
• CAS: 1338245-71-8
• 化学式: C₂₉H₁₈N₈O₄
• 分子量: 542.513
• InChiKey: DJDWCLYITZQTSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.77
• 重原子数：
  41.0
• 可旋转键数：
  6.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  186.35
• 氢给体数：
  2.0
• 氢受体数：
  10.0

反应信息

• 作为产物：
  描述：

  N'-(1-(1H-benzo[d]imidazol-2-yl)ethylidene)-2-cyanoacetohydrazide 在 哌啶 作用下， 以 乙醇 为溶剂， 反应 8.0h， 生成 1-(1-(1H-benzimidazol-2-yl)ethylideneamino)-4-(2-hydroxyphenyl)-6-(3-nitrobenzylidene-amino)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile
  参考文献：
  名称：

  A search of novel antimicrobial based on benzimidazole and 2-pyridone heterocycles

  摘要：

  The increasing incidence of bacterial drug resistance imposes a new search on existing antimicrobial drugs leading to the development of new bioactive molecules. In continuation to this, the present article deals with the synthesis and antimicrobial activity of 1-(1-(1H-benzo[d]imidazol-2-yl)ethylideneamino)-6-(arylideneamino)-4-(2-hydroxyphenyl)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitriles (4a-k). All newly synthesized compounds have been evaluated against two gram positive bacteria (Staphylococcus aureus, Streptococcus pyogenes), two gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa), and three fungi (Candida albicans, Aspergillus niger, Aspergillus clavatus) using serial broth dilution method. Compounds reported in the present article bearing chloro and hydroxy groups exhibit very good to excellent antimicrobial activity. All the newly synthesized compounds have been characterized by IR, H-1 NMR, C-13 NMR, and mass spectra.

  DOI：

  10.1007/s00044-011-9782-2