| 906007-18-9

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• CAS: 906007-18-9
• 化学式: C₃₇H₄₈N₆O₁₅
• 分子量: 816.819
• InChiKey: UCGBWNFYYPXQJL-LBFZIJHGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.56
• 重原子数：
  58.0
• 可旋转键数：
  27.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  256.27
• 氢给体数：
  1.0
• 氢受体数：
  18.0

反应信息

• 作为反应物：
  描述：

  在 ammonium hydroxide 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以0.131 g的产率得到3'-O-[4''-(17'''-azido-3''',6''',9''',12''',15'''-pentaoxaheptadecan-1'''-oxy)-5''-methoxy-2''-nitrophenylmethyl]thymidine
  参考文献：
  名称：

  A diversity oriented synthesis of 3′-O-modified nucleoside triphosphates for DNA ‘sequencing by synthesis’

  摘要：

  The nucleoside triphosphates 1, containing a photochemically cleavable group, and 2, having one that may be cleaved via palladium catalysis, were prepared as a prelude to investigating sequencing of DNA via sequencing by synthesis. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.05.035
• 作为产物：
  描述：

  3'-O-[4''-(17'''-azido-3''',6''',9''',12''',15'''-pentaoxaheptadecan-1'''-oxy)-5''-methoxy-2''-nitrophenylmethyl]-5'-O-(tert-butyldimethylsilyl)-3-N-benzoylthymidine 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以0.2104 g的产率得到
  参考文献：
  名称：

  A diversity oriented synthesis of 3′-O-modified nucleoside triphosphates for DNA ‘sequencing by synthesis’

  摘要：

  The nucleoside triphosphates 1, containing a photochemically cleavable group, and 2, having one that may be cleaved via palladium catalysis, were prepared as a prelude to investigating sequencing of DNA via sequencing by synthesis. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.05.035