(+/-)-2-hydroxy-1-(1-methyl-buten-(2)-yl)-benzene | 4204-40-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: (+/-)-2-hydroxy-1-(1-methyl-buten-(2)-yl)-benzene
• 英文别名: (+/-)-2-Hydroxy-1-(1-methyl-buten-(2)-yl)-benzol；2-Oxy-1-(α-methyl-β-butenyl)-benzol；2-(α.γ-Dimethyl-allyl)-phenol；4-(2-Oxy-phenyl)-penten-(2)；2-<2-Hydroxy-phenyl>-penten-(3)；o-(α,γ-Dimethyl-allyl)-phenol；(1-Methyl-2-butenyl)-phenol；2-pent-3-en-2-ylphenol
• CAS: 4204-40-4
• 化学式: C₁₁H₁₄O
• 分子量: 162.232
• InChiKey: ZLIBWQMBEYAPKA-UHFFFAOYSA-N

物化性质

• 沸点：
  245 °C(Press: 750 Torr)
• 密度：
  0.993 g/cm3(Temp: 15 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (+/-)-2-hydroxy-1-(1-methyl-buten-(2)-yl)-benzene 、 氯乙酸 在 sodium hydroxide 作用下， 生成 [2-(1-methyl-but-2-enyl)-phenoxy]-acetic acid
  参考文献：
  名称：

  The Rearrangement of Phenyl Allyl Ethers¹

  摘要：

  DOI：

  10.1021/ja01299a024
• 作为产物：
  描述：

  1-chloro-2-pentene 在 potassium carbonate 、 丙酮 、 N,N-二乙基苯胺 作用下， 生成 (+/-)-2-hydroxy-1-(1-methyl-buten-(2)-yl)-benzene
  参考文献：
  名称：

  The Rearrangement of Phenyl Allyl Ethers¹

  摘要：

  DOI：

  10.1021/ja01299a024

文献信息

• Prevalence of Rheumatic Fever and Rheumatic Heart Disease in Yemen
  作者：Abdul Nasser Al-Munibari、Thabet Mohsen Nasher、Siddig Ahmed Ismail、El-Daw Ahmed Mukhtar

  DOI：10.1177/021849230100900111

  日期：2001.3

  The major aim of this study was to determine the prevalence of rheumatic heart disease in Yemen. Between October 1997 and March 1998, a prospective cluster-sampling screening study was carried out on 5000 schoolchildren (2504 female and 2496 male), aged 5 to 18 years. Suspected cases were subjected to electrocardiography, chest radiography, and Doppler echocardiography. Although no case of active rheumatic fever was found, 12 girls and 6 boys were affected by the disease, giving a prevalence of 3.6 per 1000, which is higher than that reported from neighboring countries. All confirmed and suspected cases were given penicillin G benzathine every 3 weeks, according to body weight, after a test dose. Prevention programs for rheumatic fever, together with prevention of streptococcal throat infections, are goals for the near future.

  这项研究的主要目的是确定也门风湿性心脏病的患病率。在1997年10月至1998年3月期间，对5000名年龄在5至18岁之间的学童（2504名女性和2496名男性）进行了一项前瞻性集群抽样筛查研究。疑似病例接受了心电图、胸部X光和多普勒超声心动图检查。尽管未发现活动性风湿热病例，但有12名女孩和6名男孩患有该疾病，患病率为每千人3.6例，高于邻国的报道。所有确诊和疑似病例每3周按体重给予苄青霉素G，先进行试验剂量。风湿热的预防计划，以及预防链球菌喉部感染，是未来的目标。
• Modification of enteral diets in inflammatory bowel disease
  作者：Marian C. Aldhous、Doris Meister、Subrata Meister

  DOI：10.1079/pns2001120

  日期：2001.11

  The provision of food is thought to promote the maintenance of gut integrity. Nutrients are able to elicit and affect both systemic and mucosal immune responses. Enteral diet therapy has long been known to be efficacious in inflammatory bowel disease (IBD), particularly in childhood Crohn's disease. However, the mechanisms of action of these diets are not clear. Nutritional repletion, direct effects on the gut mucosa or decreased intestinal permeability have all been postulated as being important in nutritional therapy. There is some evidence that the enteral diet has a direct effect on the gut mucosa by reducing cytokine production and the accompanying inflammation, thus leading to decreased intestinal permeability. Modifications of enteral diet composition have been evaluated in many studies. Such modifications include fat and/or protein content and the addition of bioactive peptides. The fatty acid composition of the enteral diet seems to have a much greater impact on its efficacy than modification of the N source. As specific fatty acids are precursors of inflammatory mediators derived from arachidonic acid, the reduction in these components may be beneficial in nutritional therapy for IBD. Addition of bioactive peptides to enteral diet formulas may also have a role; such peptides may have specific growth factor or anti-inflammatory actions. There is still much work to be done to define disease-specific enteral diet formulas that are effective as therapies for both Crohn's disease and ulcerative colitis.

  人们认为，提供食物可以促进肠道完整性的维护。营养物质能够引起并影响全身和粘膜免疫反应。肠内饮食疗法对炎症性肠病（IBD），尤其是儿童克罗恩病（Crohn's disease）的疗效早已众所周知。然而，这些饮食的作用机制尚不清楚。营养补充、对肠道粘膜的直接影响或肠道渗透性的降低都被认为是营养疗法的重要作用。有证据表明，肠内饮食可通过减少细胞因子的产生和伴随的炎症对肠道粘膜产生直接影响，从而降低肠道渗透性。许多研究对肠内饮食成分的调整进行了评估。这些改变包括脂肪和/或蛋白质含量以及添加生物活性肽。与 N 来源的改变相比，肠内饮食的脂肪酸组成对其疗效的影响似乎更大。由于特定脂肪酸是由花生四烯酸衍生的炎症介质的前体，因此减少这些成分可能有利于 IBD 的营养治疗。在肠内饮食配方中添加生物活性肽可能也有一定作用；这类肽可能具有特定的生长因子或抗炎作用。要确定能有效治疗克罗恩病和溃疡性结肠炎的特定疾病肠道饮食配方，还有很多工作要做。
• Hurd; Cohen, Journal of the American Chemical Society, 1931, vol. 53, p. 1920
  作者：Hurd、Cohen

  DOI：——

  日期：——
• Hurd; Pollack, Journal of Organic Chemistry, 1938, vol. 3, p. 552,564
  作者：Hurd、Pollack

  DOI：——

  日期：——