(Z)-2-Hydroxy-1-(4-methoxyphenyl)-ethanone-O-methyloxime | 183986-54-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z)-2-Hydroxy-1-(4-methoxyphenyl)-ethanone-O-methyloxime
• 英文别名: (2Z)-2-methoxyimino-2-(4-methoxyphenyl)ethanol
• CAS: 183986-54-1
• 化学式: C₁₀H₁₃NO₃
• 分子量: 195.218
• InChiKey: CZYMGGNOBKBCNO-ZHACJKMWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.04
• 重原子数：
  14.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  51.05
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (Z)-2-Hydroxy-1-(4-methoxyphenyl)-ethanone-O-methyloxime 在 重铬酸吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以57%的产率得到[(Z)-Methoxyimino]-(4-methoxy-phenyl)-acetaldehyde
  参考文献：
  名称：

  1,3-Diphenylpropan-1,3-diamines IX. reaction of ?-chlorooxime ethers with ?-lithiobenzylamines

  摘要：

  The carbanions of the benzylamine derivatives 1-4 have been reacted with alpha-chlorooxime ether 5 in order to gel precursors of 1,3-diphenylpropane-1,3-diamines. Isonitrile 1 afforded the expected result, whereas lithiated benzamide 2 underwent oxidative dimerization and transmetallated chlorooxime derivative 5. Isoxazolidine 3 gave the condensation product 21 as a mixture of diastereomers; treatment of imine 4 led to the desired amine-oxime 15 in low yield.

  DOI：

  10.1007/bf00817268
• 作为产物：
  描述：

  2-羟基-1-(4-甲氧基苯基)-1-乙酮 、 甲氧基胺盐酸盐 在 吡啶 作用下， 以57%的产率得到(Z)-2-Hydroxy-1-(4-methoxyphenyl)-ethanone-O-methyloxime
  参考文献：
  名称：

  1,3-Diphenylpropan-1,3-diamines IX. reaction of ?-chlorooxime ethers with ?-lithiobenzylamines

  摘要：

  The carbanions of the benzylamine derivatives 1-4 have been reacted with alpha-chlorooxime ether 5 in order to gel precursors of 1,3-diphenylpropane-1,3-diamines. Isonitrile 1 afforded the expected result, whereas lithiated benzamide 2 underwent oxidative dimerization and transmetallated chlorooxime derivative 5. Isoxazolidine 3 gave the condensation product 21 as a mixture of diastereomers; treatment of imine 4 led to the desired amine-oxime 15 in low yield.

  DOI：

  10.1007/bf00817268