2-(2-Methylpyridin-4-YL)propan-2-amine | 566158-79-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(2-Methylpyridin-4-YL)propan-2-amine
• CAS: 566158-79-0
• 化学式: C₉H₁₄N₂
• 分子量: 150.22
• InChiKey: WKLAAQDDNJCIMM-UHFFFAOYSA-N

物化性质

• 沸点：
  241.3±25.0 °C(Predicted)
• 密度：
  0.983±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(2-Methylpyridin-4-YL)propan-2-amine 、 2-(3-(5-(2,4-difluorophenyl)isoxazole-3-carboxamido)-1-isobutylazetidin-3-yl)acetic acid 在 N,N-二异丙基乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 5-(2,4-difluorophenyl )-N-(1-isobutyl-3-(2-((2-(2-methylpyridin-4-yl)propan-2-yl)amino)-2-oxoethyl)azetidin-3-yl)isoxazole-3-carboxamide
  参考文献：
  名称：

  [EN] AZETIDINYL-ACETAMIDES AS CXCR7 INHIBITORS
  [FR] AZÉTIDINYL-ACÉTAMIDES UTILISÉS COMME INHIBITEURS DE CXCR7

  摘要：

  Compounds having formula I: (I), or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7, and treating diseases that are dependent, at least in part, on CXCR7 activity. Accordingly, the present invention provides in further aspects, compositions containing one or more of the above-noted compounds in admixture with a pharmaceutically acceptable excipient.

  公开号：

  WO2022225832A1

文献信息

• AZETIDINYL-ACETAMIDES AS CXCR7 INHIBITORS
  申请人：CHEMOCENTRYX, INC.

  公开号：US20220348568A1

  公开（公告）日：2022-11-03

  Compounds having formula I, or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7, and treating diseases that are dependent, at least in part, on CXCR7 activity. Accordingly, the present invention provides in further aspects, compositions containing one or more of the above-noted compounds in admixture with a pharmaceutically acceptable excipient.
• [EN] THIAZOLOPYRIDINE DERIVATIVES AS GPR119 AGONISTS<br/>[FR] DÉRIVÉS DE LA THIAZOLOPYRIDINE EN TANT QU'AGONISTES DU RÉCEPTEUR GPR119
  申请人：MANKIND PHARMA LTD

  公开号：WO2017175068A1

  公开（公告）日：2017-10-12

  The present invention relates to novel compounds of formula (I) as GPR119 agonist, composition compositions containing such compounds and method of preparation thereof.