1H,4H-[1,3]Thiazolo[3,4-a]benzimidazole | 38242-42-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1H,4H-[1,3]Thiazolo[3,4-a]benzimidazole
• 英文别名: 1,4-dihydro-[1,3]thiazolo[3,4-a]benzimidazole
• CAS: 38242-42-1
• 化学式: C₉H₈N₂S
• 分子量: 176.24
• InChiKey: ITFRUQJFZYEHIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  40.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] METHODS AND COMPOSITIONS FOR MODULATING DRUG ACTIVITY THROUGH TELOMERE DAMAGE<br/>[FR] METHODES ET COMPOSITIONS DESTINEES A LA MODULATION DE L'ACTION DE MEDICAMENTS PAR DETERIORATION DE TELOMERES
  申请人：AU JESSIE L S

  公开号：WO2000074667A2

  公开（公告）日：2000-12-14

  The invention provides methods and compositions for modulating the activity of therapeutic agents for the treatment of a cancer by administering one or more agents that (either alone or in combination) induces telomere damage and inhibits telomerase activity in the cancer cell. The method initially uses, e.g., a telomere damage-inducing agent such as paclitaxel, and a telomerase inhibitory agent such as AZT. The invention also provides methods for identifying other agents with telomere damage-inducing activity and/or telomerase inhibitory activity (as well as and compositions having such activity), for use in the treatment of cancer.