phenyl 2,7-di-O-benzyl-3,4-O-(2',3'-dimethoxybutane-2',3'-diyl)-L-glycero-1-thio-α-D-mannoheptopyranoside | 1060735-40-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: phenyl 2,7-di-O-benzyl-3,4-O-(2',3'-dimethoxybutane-2',3'-diyl)-L-glycero-1-thio-α-D-mannoheptopyranoside
• CAS: 1060735-40-1
• 化学式: C₃₃H₄₀O₈S
• 分子量: 596.742
• InChiKey: MCHKUDFYYNNJPF-RBSWSOLCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.18
• 重原子数：
  42.0
• 可旋转键数：
  12.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  84.84
• 氢给体数：
  1.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  phenyl 2,7-di-O-benzyl-3,4-O-(2',3'-dimethoxybutane-2',3'-diyl)-L-glycero-1-thio-α-D-mannoheptopyranoside 、 对硝基苯甲酸 在 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 以22%的产率得到
  参考文献：
  名称：

  Block Synthesis of Tetra- and Hexasaccharides (β-d-Glycero-d-manno-Hepp-(1→4)-[α-l-Rhap-(1→3)-β-d-glycero-d-manno-Hepp-(1→4)]_n-α-l-Rhap-OMe (n = 1 and 2)) Corresponding to Multiple Repeat Units of the Glycan from the Surface-Layer Glycoprotein from Bacillus thermoaerophilus

  摘要：

  A fully stereocontrolled block synthesis of the title tetra- and hexasaccharides has been achieved taking advantage of the ability of the 4,6-O-benzylidene acetal to control the stereochemistry of the beta-D-glycero-D-mannoheptopyranoside unit and of a 2,3-O-diphenylmethylene acetal to install the alpha-L-rhamnopyranosidic linkages. Comparison of the spectral data for the hexasaccharide with that of the natural isolate confirms the structure of this very unusual and structurally challenging glycan.

  DOI：

  10.1021/jo801414c
• 作为产物：
  描述：

  phenyl 2-O-benzyl-3,4-O-(2',3'-dimethoxybutane-2',3'-diyl)-L-glycero-1-thio-α-D-mannoheptopyranoside 、 溴甲苯 在 二正丁基氧化锡 、 cesium fluoride 作用下， 以 甲苯 、 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 以91%的产率得到phenyl 2,7-di-O-benzyl-3,4-O-(2',3'-dimethoxybutane-2',3'-diyl)-L-glycero-1-thio-α-D-mannoheptopyranoside
  参考文献：
  名称：

  Block Synthesis of Tetra- and Hexasaccharides (β-d-Glycero-d-manno-Hepp-(1→4)-[α-l-Rhap-(1→3)-β-d-glycero-d-manno-Hepp-(1→4)]_n-α-l-Rhap-OMe (n = 1 and 2)) Corresponding to Multiple Repeat Units of the Glycan from the Surface-Layer Glycoprotein from Bacillus thermoaerophilus

  摘要：

  A fully stereocontrolled block synthesis of the title tetra- and hexasaccharides has been achieved taking advantage of the ability of the 4,6-O-benzylidene acetal to control the stereochemistry of the beta-D-glycero-D-mannoheptopyranoside unit and of a 2,3-O-diphenylmethylene acetal to install the alpha-L-rhamnopyranosidic linkages. Comparison of the spectral data for the hexasaccharide with that of the natural isolate confirms the structure of this very unusual and structurally challenging glycan.

  DOI：

  10.1021/jo801414c