The present invention relates to novel TMPK inhibitor and their methods of use. In particular, it relates to novel TMPK inhibitor of Formula (I) and therapeutics that decrease the cellular dTTP level to suppress the growth and inhibit DNA repair in tumor cells and acts as a novel chemosensitizer, which are useful in methods for treating or preventing cancers.
本发明涉及一种新型
TMPK
抑制剂及其使用方法。具体而言,涉及一种新型公式(I)的
TMPK
抑制剂和治疗剂,可降低细胞
dTTP水平以抑制肿瘤细胞的生长和DNA修复,作为一种新型化疗增敏剂,在治疗或预防癌症的方法中有用。