2-((S)-2-Hydroxy-1-methyl-ethoxy)-propane-1,3-diol | 30628-04-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 2-((S)-2-Hydroxy-1-methyl-ethoxy)-propane-1,3-diol
• 英文别名: 1,3-Propanediol, 2-(2-hydroxy-1-methylethoxy)-, (S)-；2-[(2S)-1-hydroxypropan-2-yl]oxypropane-1,3-diol
• CAS: 30628-04-7
• 化学式: C₆H₁₄O₄
• 分子量: 150.175
• InChiKey: ZKIOTKCGNGCWRC-YFKPBYRVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  69.9
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Chemically Ligated RNAs for CRISPR/Cas9-lgRNA Complexes as Antiviral Therapeutic Agents
  申请人：Zhong Minghong

  公开号：US20160215275A1

  公开（公告）日：2016-07-28

  Provided herein are chemically ligated guide RNA oligonucleotides (lgRNA) which comprise two functional RNA modules (crgRNA and tracrgRNA) joined by non-nucleotide chemical linkers (nNt-linker), their complexes with CRISPR-Cas9, preparation methods of Cas9-lgRNA complexes, and their uses for treatments of viral infections in humans. Also disclosed are processes and methods for preparation of these compounds.