2-Anilino-2-methyl-4-phenyl-but-3-en-nitril | 17424-74-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Anilino-2-methyl-4-phenyl-but-3-en-nitril
• CAS: 17424-74-7
• 化学式: C₁₇H₁₆N₂
• 分子量: 248.327
• InChiKey: UHRGWBAXOGNZFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.09
• 重原子数：
  19.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  35.82
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  三甲基氰硅烷 、 苯胺 、 苄叉丙酮 在 Sn-exchanged HBeta zeolite 作用下， 反应 2.0h， 以25%的产率得到2-Anilino-2-methyl-4-phenyl-but-3-en-nitril
  参考文献：
  名称：

  Tin exchanged zeolite as catalyst for direct synthesis of α-amino nitriles under solvent-free conditions

  摘要：

  Sn exchanged HBeta zeolite was prepared and characterized by PXRD, surface area, TPD and TEM analysis. The Sn exchanged zeolite was found to be highly efficient catalyst for the direct synthesis of alpha-amino nitrite from various ketones and aldehydes with amine and trimethyl silylcyanide (TMSCN) under solvent-free condition. Excellent yield of alpha-amino nitrile (up to 96%) was achieved within 10-120 min at room temperature. The Sn exchanged HBeta zeolite was recovered and reused several times without the loss of its catalytic performance. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.apcata.2012.01.001

文献信息

• A novel approach for the synthesis of α-aminonitriles using Mitsunobu’s reagent under solvent-free conditions
  作者：Devdutt Chaturvedi、Amit K. Chaturvedi、Nisha Mishra、Virendra Mishra

  DOI：10.1016/j.tetlet.2012.07.117

  日期：2012.10

  A highly efficient, one-pot, three-component, solvent-free protocol for the synthesis of alpha-aminonitriles starting from their corresponding carbonyl compounds, amines, using Mitsunobu's reagent has been developed. Diversity of alpha-aminonitriles has been synthesized in good to excellent yields (80-99%) using various kinds of aldehydes/ketones and a variety of amines. (C) 2012 Elsevier Ltd. All rights reserved,