1-acetyl-2-methyltetrahydropyrimidine | 52776-54-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-acetyl-2-methyltetrahydropyrimidine
• 英文别名: 1-acetyl-2-methyl-1,4,5,6-tetrahydro-pyrimidine；1-(2-methyl-5,6-dihydro-4H-pyrimidin-1-yl)ethanone
• CAS: 52776-54-2
• 化学式: C₇H₁₂N₂O
• 分子量: 140.185
• InChiKey: VSZXRPRPCUALPH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  32.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-acetyl-2-methyltetrahydropyrimidine 、 碘甲烷 反应 5.0h， 以70%的产率得到1-acetyl-2,3-dimethyltetrahydropyrimidinium iodide
  参考文献：
  名称：

  Tetrahydropyrimidine Derivatives as Efficient Organic Reductants for Transfer Hydrogenation

  摘要：

  Two six-membered heterocyclic organic reductants, 1-acetyl-2,3-dimethyltetrahydropyrimidine (ADMP) and 1-tosyl-2,3-dimethyltetrahydropyrimidine (TDMP), were designed and synthesized for transfer hydrogenation. It was shown that both the two reductants could directly reduce a variety of aldehydes and imines to the corresponding saturated products in good yields.

  DOI：

  10.3987/com-08-11603
• 作为产物：
  描述：

  2-甲基-1,4,5,6-四氢嘧啶 、 乙酰氯 以28%的产率得到
  参考文献：
  名称：

  OKADA JUTARO; SHIMABAYASHI MASAHARU, YAKUGAKU DZASSI, YAKUGAKU ZASSNI,

  摘要：

  DOI：

文献信息

• Melanocortin-4 receptor binding compounds and methods of use thereof
  申请人：Vos Tricia J.

  公开号：US20080269217A1

  公开（公告）日：2008-10-30

  Provided are MC4-R binding compounds of the formula XVII: wherein L 2 is a linker group, and P 1 , P 2 , P 3 , P 4 , Z 1 , Z 2 , Z 3 , Z 4 , Z 5 , t, s, and R are as described in the specification. Methods of using the compounds to treat MC4-R associated disorders, such as disorders associated with weight loss, are also provided.

  提供的是公式XVII的MC4-R结合化合物： 其中L2是连接基团，而P1，P2，P3，P4，Z1，Z2，Z3，Z4，Z5，t，s和R如规范所述。还提供了使用这些化合物治疗MC4-R相关疾病的方法，例如与体重减轻相关的疾病。
• HAIR COLORING COMPOSITION AND METHODS FOR ITS APPLICATION AND REMOVAL
  申请人：HFC Prestinge International Holding Switzerland S.a.r.l.

  公开号：US20210220251A1

  公开（公告）日：2021-07-22

  The instant disclosure generally relates to a coloring composition for coloring mammalian or synthetic keratin fibers or keratinous surfaces. The composition comprising a medium, optionally pigment microparticles and at least one dye, in particular at least one peri-arylene dye dissolved in the medium. Methods of using such compositions are also described herein.
• US7375125B2
  申请人：——

  公开号：US7375125B2

  公开（公告）日：2008-05-20