3-溴咪唑[1,2-A]吡啶-2-羧酸 | 354548-73-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 中文名称: 3-溴咪唑[1,2-A]吡啶-2-羧酸
• 中文别名: 3-溴咪唑并[1,2-A]吡啶-2-羧酸
• 英文名称: 3-Bromoimidazo[1,2-a]pyridine-2-carboxylic acid
• CAS: 354548-73-5
• 化学式: C₈H₅BrN₂O₂
• 分子量: 241.044
• InChiKey: UHBDEEITGHGHKK-UHFFFAOYSA-N

物化性质

• 密度：
  1.89±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  1-[2-(2,4-difluorophenyl)ethyl]piperazine 、 3-溴咪唑[1,2-A]吡啶-2-羧酸 在 三乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 作用下， 以 四氢呋喃 为溶剂， 生成 (3-Bromoimidazo[1,2-a]pyridin-2-yl)-[4-[2-(2,4-difluorophenyl)ethyl]piperazin-1-yl]methanone
  参考文献：
  名称：

  Identification of fused bicyclic heterocycles as potent and selective 5-HT2A receptor antagonists for the treatment of insomnia

  摘要：

  A series of fused bicyclic heterocycles was identified as potent and selective 5-HT2A receptor antagonists. Optimization of the series resulted in compounds that had improved PK properties, favorable CNS partitioning, good pharmacokinetic properties, and significant improvements on deep sleep (delta power) and sleep consolidation. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.01.080
• 作为产物：
  描述：

  咪唑吡啶-2-羧酸乙酯 在 乙醇 、 溴 、 sodium hydroxide 作用下， 以 溶剂黄146 为溶剂， 生成 3-溴咪唑[1,2-A]吡啶-2-羧酸
  参考文献：
  名称：

  Identification of fused bicyclic heterocycles as potent and selective 5-HT2A receptor antagonists for the treatment of insomnia

  摘要：

  A series of fused bicyclic heterocycles was identified as potent and selective 5-HT2A receptor antagonists. Optimization of the series resulted in compounds that had improved PK properties, favorable CNS partitioning, good pharmacokinetic properties, and significant improvements on deep sleep (delta power) and sleep consolidation. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.01.080

文献信息

• [EN] SUBSTITUTED HETEROARYL FUSED DERIVATIVES AS PI3K INHIBITORS<br/>[FR] DÉRIVÉS CONDENSÉS D'HÉTÉROARYLES SUBSTITUÉS À TITRE D'INHIBITEURS DE PI3K
  申请人：INCYTE CORP

  公开号：WO2011075643A1

  公开（公告）日：2011-06-23

  The present invention provides fused derivatives of Formula (I) that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PBKs including, for example, inflammatory disorders, immune- based disorders, cancer, and other diseases.

  本发明提供了公式（I）的融合衍生物，可调节磷脂酰肌醇3-激酶（PI3Ks）的活性，并在治疗与PBKs活性相关的疾病方面具有用处，例如炎症性疾病、免疫性疾病、癌症和其他疾病。
• SUBSTITUTED HETEROARYL FUSED DERIVATIVES AS PI3K INHIBITORS
  申请人：Combs Andrew P.

  公开号：US20110190319A1

  公开（公告）日：2011-08-04

  The present invention provides fused derivatives of Formula I: that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.

  本发明提供了公式I的融合衍生物，其调节磷脂酰肌醇3-激酶（PI3Ks）的活性，并且在治疗与PI3Ks活性相关的疾病方面具有用途，例如，炎症性疾病、免疫相关疾病、癌症和其他疾病。
• NEMATOCIDAL SULFONAMIDES
  申请人：Lahm George Philip

  公开号：US20120114624A1

  公开（公告）日：2012-05-10

  Disclosed are compounds of Formula 1, N-oxides, and salts thereof, wherein Z is O or S; and R 1 , R 2 , R 3 , Q and n are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling a parasitic nematode comprising contacting the parasitic nematode or its environment with a biologically effective amount of a compound or a composition of the invention.

  本发明涉及一种化合物，其分子式为1，N-氧化物及其盐，其中Z为O或S; R1，R2，R3，Q和n如所述。本发明还涉及含有该化合物的组合物以及使用该化合物或该组合物与寄生线虫或其环境接触以控制寄生线虫的方法。
• Heterocyclic sulfonylamino(thio)carbonyl-derivatives with nematicidal properties
  申请人：BAYER CROPSCIENCE AG

  公开号：US20160159805A1

  公开（公告）日：2016-06-09

  Disclosed are compounds of formula (I) which possess nematicidal properties wherein the residues have the meaning as indicated in the description.

  本发明涉及一种具有线虫杀灭活性的化合物（I）,其中残基的含义如说明中所示。
• US20140275127A1
  申请人：——

  公开号：US20140275127A1

  公开（公告）日：2014-09-18