6-methylthieno[2,3-b]pyrrole-5-carboxylic acid | 1554281-31-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡咯类
• 英文名称: 6-methylthieno[2,3-b]pyrrole-5-carboxylic acid
• 英文别名: 6-methyl-6H-thieno[2,3-b]pyrrole-5-carboxylic acid
• CAS: 1554281-31-0
• 化学式: C₈H₇NO₂S
• 分子量: 181.215
• InChiKey: GKQQTOVFGYGERC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  70.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• IMIDAZOLES AS HISTONE DEMETHYLASE INHIBITORS
  申请人：Istituto Europeo di Oncologia S.r.l.

  公开号：EP3246330A1

  公开（公告）日：2017-11-22

  The present invention relates to imidazole derivatives, wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.

  本发明涉及咪唑衍生物，其中A、R、R1和R2如规范中定义，含有这种化合物的药物组合物以及它们在治疗中的用途。
• [EN] INDOLE DERIVATIVES AS HISTONE DEMETHYLASE INHIBITORS<br/>[FR] DÉRIVÉS D'INDOLE UTILISÉS EN TANT INHIBITEURS DE L'HISTONE DÉMÉTHYLASE
  申请人：ST EUROPEO DI ONCOLOGIA IEO S R L

  公开号：WO2019034774A1

  公开（公告）日：2019-02-21

  The present application relates to compounds of formula (I), wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.

  本申请涉及到式(I)的化合物，其中A、R、R1和R2如规范中定义，包含这些化合物的药物组合物以及它们在治疗中的应用。
• Thienopyrroles as histone demethylase inhibitors
  申请人：IEO - Istituto Europeo di Oncologia Srl

  公开号：EP2993175A1

  公开（公告）日：2016-03-09

  The present invention relates to thienopyrrole derivatives, wherein R, R1, R2 and R3 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.

  本发明涉及噻吩吡咯衍生物（其中 R、R1、R2 和 R3 如说明书中所定义）、含有此类化合物的药物组合物及其在治疗中的用途。
• Imidazoles as histone demethylase inhibitors
  申请人：Istituto Europeo di Oncologia S.r.l.

  公开号：US10562914B2

  公开（公告）日：2020-02-18

  The present invention relates to imidazole derivatives of Formula (I), wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.

  本发明涉及式（I）的咪唑衍生物（其中 A、R、R1 和 R2 如说明书中所定义）、含有此类化合物的药物组合物及其在治疗中的应用。
• Indole derivatives as histone demethylase inhibitors
  申请人：Istituto Europeo di Oncologia S.r.l.

  公开号：US10980777B2

  公开（公告）日：2021-04-20

  The present application relates to compounds of formula (I), wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.

  本申请涉及式（I）化合物（其中 A、R、R1 和 R2 如说明书中所定义）、含有此类化合物的药物组合物及其在治疗中的应用。