5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]pyrazin-2-amine | 1431293-90-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]pyrazin-2-amine
• 英文别名: 5-[2-Methyl-5-(trifluoromethyl)pyrazol-3-yl]pyrazin-2-amine
• CAS: 1431293-90-1
• 化学式: C₉H₈F₃N₅
• 分子量: 243.191
• InChiKey: GXDCIZKFRLGISJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  69.6
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• New bicyclic compounds as crac channel modulators
  申请人：Almirall, S.A.

  公开号：EP2738172A1

  公开（公告）日：2014-06-04

  The present invention relates to novel compounds which are inhibitors of CRAC channel activity. This invention also relates to pharmaceutical compositions containing them, process for their preparation and their use in therapy.

  这项发明涉及一种新型化合物，它们是CRAC通道活性的抑制剂。该发明还涉及含有这些化合物的药物组合物，它们的制备方法以及它们在治疗中的应用。
• US20140256745A1
  申请人：——

  公开号：US20140256745A1

  公开（公告）日：2014-09-11
• US9856240B2
  申请人：——

  公开号：US9856240B2

  公开（公告）日：2018-01-02
• [EN] COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM<br/>[FR] COMPOSÉS QUI MODULENT LE CALCIUM INTRACELLULAIRE
  申请人：CALCIMEDICA INC

  公开号：WO2013059677A1

  公开（公告）日：2013-04-25

  Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.