(2R,4R,4aS)-4-[amino-(3,5-bistrifluoromethyl-phenyl)-methyl]-2-methyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid isopropyl ester | 880545-79-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (2R,4R,4aS)-4-[amino-(3,5-bistrifluoromethyl-phenyl)-methyl]-2-methyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid isopropyl ester
• 英文别名: propan-2-yl (2R,4R)-4-[(S)-amino-[3,5-bis(trifluoromethyl)phenyl]methyl]-2-methyl-6-(trifluoromethyl)-3,4-dihydro-2H-quinoline-1-carboxylate
• CAS: 880545-79-9
• 化学式: C₂₄H₂₃F₉N₂O₂
• 分子量: 542.444
• InChiKey: DNCKLPHLWHGSHF-ZQBYOIRZSA-N

物化性质

• 沸点：
  444.3±45.0 °C(Predicted)
• 密度：
  1.350±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  37
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  12

文献信息

• Quinoline compounds
  申请人：Didiuk Mary

  公开号：US20070149567A1

  公开（公告）日：2007-06-28

  Quinoline compounds, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDLcholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.